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BACKGROUND Treatment with peginterferon alfa-2a alone produces significantly higher sustained virologic responses than treatment with interferon alfa-2a alone in patients with chronic hepatitis C virus (HCV) infection. We compared the efficacy and safety of peginterferon alfa-2a plus ribavirin, interferon alfa-2b plus ribavirin, and peginterferon alfa-2a(More)
In this paper, we study the restoration of images corrupted by Gaussian plus impulse noise, and propose a l 1 –l 0 minimization approach where the l 1 term is used for impulse denoising and the l 0 term is used for a sparse representation over certain unknown dictionary of images patches. The main algorithm contains three phases. The first phase is to(More)
Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA mismatch repair in a variety of tissues. PMS2-deficient(More)
DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells. Using whole-genome bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand), we report a comprehensive (92.62%) methylome and(More)
Netrins are an important family of axon guidance cues. Here, we report that netrin-1 induces tyrosine phosphorylation of p130(CAS) (Crk-associated substrate). Our biochemical studies indicate that p130(CAS) is downstream of the Src family kinases and upstream of the small GTPase Rac1 and Cdc42. Inhibition of p130(CAS) signaling blocks both the neurite(More)
With increasing adoption and presence of Web services, designing novel approaches for efficient Web services recommendation has become steadily more important. Existing Web services discovery and recommendation approaches focus on either perishing UDDI registries, or keyword-dominant Web service search engines, which possess many limitations such as(More)
Kallikrein, a serine proteinase, has been identified as an angiogenic growth factor recently. We investigated whether delayed treatment with exogenous kallikrein enhances neurogenesis and angiogenesis after focal cortical infarction in stroke-prone renovascular hypertensive rats. Human tissue kallikrein (1.6 x 10(-2) PNAU/kg) or vehicle was given through a(More)
Brushless doubly-fed induction machines (BDFIMs) have been extensively researched over the last 15 years because of the possibility of using a partially rated inverter in many applications with limited speed variations. However, the special cage rotor construction and substantial rotor losses is one of the key deficiencies of these machines. A similar and(More)
An important challenge for the adoption of cloud computing in the scientific community remains the efficient allocation and execution of data-intensive scientific workflows to reduce execution time and the size of transferred data. The transferred data overhead is becoming significant with emerging scientific workflows that have input/output files and(More)