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Involvement of Selective Reactive Oxygen Species Upstream of Proapoptotic Branches of Unfolded Protein Response*
Cadmium triggers apoptosis of LLC-PK1 cells through induction of endoplasmic reticulum (ER) stress and that cadmium-induced ER stress was inhibited by antioxidants, suggesting that ER stress occurs downstream of oxidative stress.
Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP).
Activation of the Akt-NF-κB Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response1
Results suggested that loss of GRP78 by SubAB leads to transient phosphorylation of Akt and consequent activation of NF-κB through the ATF6 branch of the UPR.
Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia
The results elucidated for the first time a possible involvement of transient, systemic ER stress in endotoxemia and provided evidence for usefulness of ER stress responsive alkaline phosphatase for real-time monitoring of ER Stress in vitro and in vivo.
Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt
- S. Nakajima, N. Hiramatsu, M. Kitamura
- Chemistry, BiologyMolecular and Cellular Biology
- 7 February 2011
It is elucidated that SubAB blunts activation of NF-κB through ATF6-dependent mechanisms, i.e., preferential induction of C/EBPβ and mTOR-dependent dephosphorylation of Akt.
Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice
High levels of dioxin-like potential in cigarette smoke evidenced by in vitro and in vivo biosensing.
- A. Kasai, N. Hiramatsu, K. Hayakawa, Jian Yao, S. Maeda, M. Kitamura
- Biology, ChemistryCancer research
- 15 July 2006
It is evidenced for the first time that cigarette smoke has unexpectedly high dioxin-like potential that triggers the AhR-XRE pathway in vitro and in vivo.
Up-regulation of connexin43 in glomerular podocytes in response to injury.
Gap Junction-Mediated Intercellular Communication between Dendritic Cells (DCs) Is Required for Effective Activation of DCs1
This study provides the first evidence for GJIC between DCs, which is required for effective DC activation, and significantly inhibited the dye-coupling and activation of heptanol, a gap junction blocker.
ER stress depresses NF-kappaB activation in mesangial cells through preferential induction of C/EBP beta.
The results suggest that ER stress blunts cytokine-triggered activation of NF-kappaB, in part through PERK- and IRE1-mediated preferential induction of C/EBPbeta.