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Privacy becomes a more and more serious concern in applications involving microdata. Recently, efficient anonymization has attracted much research work. Most of the previous methods use global recoding, which maps the domains of the quasi-identifier attributes to generalized or changed values. However, global recoding may not always achieve effective(More)
498 0740-7475/05/$20.00 © 2005 IEEE Copublished by the IEEE CS and the IEEE CASS IEEE Design & Test of Computers AN INCREASING NUMBER of integrated solutions involve the stacking of chips to reduce system size. You can find wire-bonded stacks of processors and memories in cell phones, PDAs, and flash cards. But is physical size of the system the only(More)
The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and(More)
Escherichia coli is a model laboratory bacterium, a species that is widely distributed in the environment, as well as a mutualist and pathogen in its human hosts. As such, E. coli represents an attractive organism to study how environment impacts microbial genome structure and function. Uropathogenic E. coli (UPEC) must adapt to life in several microbial(More)
Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively(More)
Helicobacter pylori produces acute superficial gastritis in nearly all of its human hosts. However, a subset of individuals develops chronic atrophic gastritis (ChAG), a condition characterized in part by diminished numbers of acid-producing parietal cells and increased risk for development of gastric adenocarcinoma. Previously, we used a gnotobiotic(More)
Multimeric assemblies of kainate (KA) receptor subunits form glutamate-gated ion channels that mediate EPSCs and function as presynaptic modulators of neurotransmitter release at some central synapses. The KA2 subunit is a likely constituent of many neuronal kainate receptors, because it is widely expressed in most neurons in the CNS. We have studied the(More)
Current data centers require storage capacities of hundreds of terabytes to petabytes. Time-critical applications such as on-line transaction processing depend on getting adequate performance from the storage subsystem; otherwise, they fail. It is difficult to provide predictable quality of service at this level of complexity, because I/O workloads are(More)
Soluble oligomers of amyloid beta (Abeta) play a role in the memory impairment characteristic of Alzheimer's disease. Acting as pathogenic ligands, Abeta oligomers bind to particular synapses and perturb their function, morphology, and maintenance. Events that occur shortly after oligomer binding have been investigated here in live hippocampal neurons by(More)