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Cimicifugae Rhizoma, mainly originated from C. acerina, C. dahurica, C. foetida, C. heracleifolia, C. racemosa and C. simplex, has long been used in traditional medicine system. During the past 45 years, a lot of efforts have been dedicated to the studies on their bioactive constituents, pharmacological effects and clinical uses, and a variety of biological(More)
This study was conducted to investigate the effects of fluoride on pancreatic digestive enzyme activities and ultrastructure in young pigs. Three groups of crossbred barrows were exposed to 100, 250, and 400 mg F–/kg (from NaF) in their diets for 50 days. Compared to a control group, the activities of pancreatic lipase and protease (but not amylase) were(More)
Bioassay-directed fractionation of a butanol-soluble fraction of methanol extract of the root of Achyranthes bidentata resulted in the isolation of 5 new oleanolic acid glycosides 1-5, namely, 18-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3beta-yl 3-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosiduronic acid methyl ester (1), achyranthoside C dimethyl(More)
This study was conducted to investigate effects of fluoride on lipid peroxidation and antioxidant systems in young pigs. Three groups of crossbred barrows about 50 days old were exposed to 100, 250, and 400 mg F–/kg (from NaF) in their diets for 50 days. Serum malondialdehyde (MDA) and nitric oxide (NO) levels were significantly increased, and the(More)
AIM OF THE STUDY A Chinese herbal drug, root of Achyranthes bidentata showed a potent inhibitory activity on bone resorption induced by parathyroid hormone (PTH) in a bone organ culture using neonatal mouse parietal bones. The present study is to clarify the fractions responsible for the activity and further explore the osteoprotective effect of the(More)
Oleanolic acid with anti-bone resorption effect was an active component discovered in a medicinal plant of Achyranthes bidentata. A series of heterocyclic derivatives of oleanolic acid including indole, pyrazine, quinoxaline, quinoline moieties and their natural amino acid amides were synthesized. Their inhibitory activity on the formation of(More)
The currently accepted approaches to treatment of pulmonary fibrosis are based on the treatment of alveolitis and pulmonary fibrosis, however clinically available anti-inflammatory and antifibrotic agents are not often beneficial. Hu-qi-yin, one of the traditional Chinese herbal formulas, has been used for clinical therapy of pulmonary fibrosis in China.(More)