Jian Xia

Learn More
Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However, the role of CLU on AD pathogenesis is not totally understood. We used cerebrospinal fluid (CSF) and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not plasma, CLU levels were significantly(More)
We establish two new lower bounds for the halfspace range searching problem: Given a set of <i>n</i> points in &#8476;<sup><i>d</i></sup>, where each point is associated with a weight from a commutative semigroup, compute the semigroup sum of the weights of the points lying within any query halfspace. Letting $m$ denote the space requirements, we prove a(More)
We consider approximate nearest neighbor searching in metric spaces of constant doubling dimension. More formally, we are given a set S of n points and an error bound ε > 0. The objective is to build a data structure so that given any query point q in the space, it is possible to efficiently determine a point of S whose distance from q is within a factor of(More)
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes, and multiple(More)
Protein Z (PZ) and factor (F) VII are two important factors in the clotting pathway which have similar structure, linked function and nearby gene sites. The aims of this study were to investigate whether the common variants of PZ and FVII genes are associated with the risk of cerebral hemorrhage (CH) and to explore the combined effects of PZ and FVII(More)
  • 1