Jian Xia

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We establish two new lower bounds for the halfspace range searching problem: Given a set of <i>n</i> points in &#8476;<sup><i>d</i></sup>, where each point is associated with a weight from a commutative semigroup, compute the semigroup sum of the weights of the points lying within any query halfspace. Letting $m$ denote the space requirements, we prove a(More)
We consider approximate nearest neighbor searching in metric spaces of constant doubling dimension. More formally, we are given a set S of n points and an error bound ε > 0. The objective is to build a data structure so that given any query point q in the space, it is possible to efficiently determine a point of S whose distance from q is within a factor of(More)
Transcriptional silencing of the Fmr1 gene encoding fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), the most common form of inherited intellectual disability and the leading genetic cause of autism. FMRP has been suggested to play important roles in regulating neurotransmission and short-term synaptic plasticity at excitatory(More)
  • Yuetiva Deming, Jian Xia, Yefei Cai, Jenny Lord, Jorge L. Del-Aguila, Maria Victoria Fernandez +342 others
  • 2016
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes, and multiple(More)
The aim of the study was to investigate the expression of miR-223 and FAM5C in the peripheral blood mononuclear cells (PBMCs) of cerebral infarction patients with or without diabetes. Sixteen cases with diabetes mellitus (DM), 14 cases with cerebral infarction (CI), 12 cases with cerebral infarction and diabetes mellitus (CIDM), and 18 healthy subjects were(More)
Herein we describe the discovery of compounds that are competitive antagonists of the CP101-606 binding site within the NR2B subtype of the NMDA receptor. The compounds identified do not possess phenolic functional groups such as those in ifenprodil and related analogs. Initial identification of hits in this series focused on a basic, secondary amine side(More)
BACKGROUND AND PURPOSE Although we demonstrated willed movement (WM) therapy can facilitate the patients actively participating in the physical activities by cognitive and perceptual stimulation in our previous study, the molecular mechanisms of the willed movement on the patients remains unclear. We initially established the model of WM intervention for(More)
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