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Rett syndrome is an autism spectrum disorder caused by mosaic expression of mutant copies of the X-linked MECP2 gene in neurons. However, neurons do not die, which suggests that this is not a neurodegenerative disorder. An important question for future therapeutic approaches to this and related disorders concerns phenotypic reversibility. Can viable but(More)
The success story of fast-spiking, parvalbumin-positive (PV(+)) GABAergic interneurons (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy. In 1995, the properties of these interneurons were completely unknown. Twenty years later, thanks to the massive use of subcellular patch-clamp techniques, simultaneous multiple-cell(More)
A study was made to determine the disposition of vesicle-associated proteins (syntaxin, SV2, SNAP-25) and calcium channels with respect to the spatial extent of spontaneous and evoked quantal release within regions of amphibian motor-nerve terminal branches delineated by FM1-43 stained vesicle clusters (blobs). Discrete concentrations of vesicles revealed(More)
Anonymity is one of the main virtues of the Internet, as it protects privacy and enables users to express opinions more freely. However, anonymity hinders the assessment of the veracity of assertions that online users make about their identity attributes, such as age or profession. We propose FaceTrust, a system that uses online social networks to provide(More)
The hippocampus plays a key role in learning and memory. Previous studies suggested that the main types of principal neurons, dentate gyrus granule cells (GCs), CA3 pyramidal neurons, and CA1 pyramidal neurons, differ in their activity pattern, with sparse firing in GCs and more frequent firing in CA3 and CA1 pyramidal neurons. It has been assumed but never(More)
Anonymity is one of the main virtues of the Internet, as it protects privacy and enables users to express opinions more freely. However, anonymity hinders the assessment of the veracity of assertions that online users make about their identity attributes, such as age or profession. We propose FaceTrust, a system that uses online social networks to provide(More)
Anonymity is one of the main virtues of the Internet, as it protects privacy and enables users to express opinions more freely. However, anonymity hinders the assessment of the veracity of assertions that online users make about their identity attributes, such as age or profession. We propose FaceTrust, a system that uses online social networks to provide(More)
Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation during non-rapid eye movement sleep, immobility, and consummatory behavior. However, whether temporally modulated synaptic excitation or inhibition underlies the ripples is controversial. To address this question, we performed simultaneous recordings of excitatory and inhibitory(More)
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