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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy.
TLDR
It is shown that exosomes modified by targeting ligands can be used therapeutically for the delivery of Dox to tumor tissue in BALB/c nude mice, thus having great potential value for clinical applications. Expand
Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.
A series of novel dithiocarbamate-chalcone derivates were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell lines (EC-109, SK-N-SH and MGC-803).Expand
Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.
TLDR
Cy-3-glu presents the protective role against oxidative stress induced by AA in MDA-MB-231 cells, significantly inhibited AA-induced cytotoxicity, reduced reactive oxygen species (ROS) generation, and recovered glutathione (GSH) depletion. Expand
Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.
A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC-109, PC-3). TheExpand
Genotoxicity assessment of an energetic propellant compound, 3-nitro-1,2,4-triazol-5-one (NTO).
TLDR
Investigation of genotoxicity of NTO and potential in vivo clastogenicity and aneugenicity suggest a low risk of genetic hazards associated with exposure and reveal that NTO was not genotoxic in either in vitro or in vivo tests. Expand
Design, synthesis and antiproliferative activity studies of 1,2,3-triazole–chalcones
A series of 1,2,3-triazole–chalcone hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, HepG-2 and MGC-803). MostExpand
Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress.
TLDR
The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH and the toxicity remained on long-term low-dose condition. Expand
Genotoxicity assessment of two hypergolic energetic propellant compounds.
TLDR
It is demonstrated that DMAZ is mutagenic in specific strains of Salmonella, and both compounds were negative for induction of chromosomal aberrations in CHO cells in vitro and in the in vivo mouse micronucleus assay. Expand
Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli.
TLDR
A GPx4 mutant with all Cys residues converted to Ser exhibited a "Ping-Pong" mechanism and structure similar to that of native GPx 4, indicating that it could act as a substitute for GPx3, when heterologously expressing the protein in E. coli. Expand
Efficient Expression of Glutathione Peroxidase with Chimeric tRNA in Amber-less Escherichia coli.
TLDR
This approach enables efficient selenoprotein expression in amber-less Escherichia coli and should enable further characterization of seleniproteins in vitro. Expand
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