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Posttranslational modifications of proteins by small ubiquitin-like modifiers (SUMOs) regulate protein degradation and localization, protein-protein interaction, and transcriptional activity. SUMO E3 ligase functions are executed by SIZ1/SIZ2 and Mms21 in yeast, the PIAS family members RanBP2, and Pc2 in human. The Arabidopsis thaliana genome contains only(More)
In the last several years hundreds of thousands of SSDs have been deployed in the data centers of Baidu, China's largest Internet search company. Currently only 40\% or less of the raw bandwidth of the flash memory in the SSDs is delivered by the storage system to the applications. Moreover, because of space over-provisioning in the SSD to accommodate(More)
Various key-value (KV) stores are widely employed for data management to support Internet services as they offer higher efficiency, scalability, and availability than relational database systems. The log-structured merge tree (LSM-tree) based KV stores have attracted growing attention because they can eliminate random writes and maintain acceptable read(More)
S-Adenosyl-L-methionine:phosphoethanolamine N-methyltransferase (PEAMT; EC catalyzes the key step in choline (Cho) biosynthesis, the N-methylation of phosphoethanolamine. Cho is a vital precursor of the membrane phospholipid phosphatidylcholine, which accounts for 40 to 60% of lipids in nonplastid plant membranes. Certain plants use Cho to(More)
Epigenetic regulation of gene expression by histone-modifying corepressor complexes is central to normal animal development. The NAD(+)-dependent deacetylase and gene repressor SIRT1 removes histone H4K16 acetylation marks and facilitates heterochromatin formation. However, the mechanistic contribution of SIRT1 to epigenetic regulation at euchromatic loci(More)
NAND flash based solid state drives (SSDs) have been widely adopted as storage devices in modern data centers to provide high performance I/O services. Recently, researchers proposed several schemes to improve energy efficiency of the system by off-loading specific computation tasks from generic processors to local processing elements in SSD controllers.(More)
SLX4, a coordinator of multiple DNA structure-specific endonucleases, is important for several DNA repair pathways. Noncovalent interactions of SLX4 with ubiquitin are required for localizing SLX4 to DNA interstrand crosslinks (ICLs), yet how SLX4 is targeted to other functional contexts remains unclear. Here, we show that SLX4 binds SUMO-2/3 chains via(More)
The plant tryptophan (Trp) biosynthetic pathway produces many secondary metabolites with diverse functions. Indole-3-acetic acid (IAA), proposed as a derivative from Trp or its precursors, plays an essential role in plant growth and development. Although the Trp-dependant and Trp-independent IAA biosynthetic pathways have been proposed, the enzymes,(More)
Posttranslational modification of transcription factors by the small ubiquitin-related modifier SUMO is associated with transcriptional repression, but the underlying mechanisms remain incompletely described. We have identified binding of the LSD1/CoREST1/HDAC corepressor complex to SUMO-2. Here we show that CoREST1 binds directly and noncovalently to(More)