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A genomic scan for age at onset of alzheimer's disease in 437 families from the NIMH genetic initiative
TLDR
Results replicate previous findings, but identify additional suggestive peaks indicating the genetics of AAO in AD is complex with many chromosomal regions potentially containing modifying genes.
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MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males
TLDR
Haplotype analysis showed that the CGATATGT sequence mediated decreased alcohol-induced ONFH risk and MMP-8 rs11225394 increases it, among Chinese males.
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Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI).
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In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment
TLDR
Results indicated ZINC67913374 bound to PARP1 with a higher affinity, which suggest ZINC67813374 has promising potential for cancer drug development.
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Association between CYP17A1 rs3824755 and rs743572 gene polymorphisms and Alzheimer’s disease in the Chinese Han population
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Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese
TLDR
The present meta-analysis suggests that the PON1 Q192R polymorphism has a weak association with CHD risk in Chinese.
View on Wolters Kluwer
Impact of interaction between the G870A and EFEMP1 gene polymorphism on glioma risk in Chinese Han population
TLDR
Polymorphism in rs603965 within CCND1 gene and rs1346787 within EFEMP1 geneand its gene- gene interaction were associated with increased glioma risk.
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CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer’s disease in the Chinese Han population
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Association between genetic polymorphisms of MMP8 and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China
TLDR
It is verified that genetic variants of MMP8 contribute to steroid-induced ONFH susceptibility in the population of northern China and that gender differences might interact with M MP8 polymorphisms to contribute to the overall susceptibility to steroid.
View on Wolters Kluwer
The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population
TLDR
The results demonstrated that the rs3751592 A/G polymorphism of the CYP19A1 gene was associated with the incidence of AD in a Chinese Han population, which suggests that CYP 19A1 rs375 1592 is a predisposing genetic factor for AD.
View on Wolters Kluwer
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