Jian-Jun Chang

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The immune responses induced by Microtus brandti lactate dehydrogenase C4 DNA vaccine via oral feeding and nasal instillation in mouse were investigated. The number of newborns of the vaccinated mice was statistically significantly reduced compared with the control mice, but the vaccine failed to affect the birthrate, as all vaccinated mice gave birth.
Partial cDNA sequence coding for Microtus brandti radde (Brandt's vole) testes-specific lactate dehydrogenase (brLDH-C4) was amplified by reverse transcription-polymerase chain reaction (RT-PCR). By inserting the product into the eukaryotic expression vector pCR3.1, pCR3.1-brLDH-C4' was obtained as the prototype of contraceptive DNA vaccine. Immunization(More)
Purpose: The purpose of this study was to validate the efficacy and safety of single-stage posterior debridement bone grafting for treatment of lumbar spinal tuberculosis with kyphotic deformity (LSTKD). Methods: From June 2010 to June 2013, 48 patients were enrolled in this study. Total 27 and 21 patients underwent single-stage posterior and anterior(More)
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