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BACKGROUND Angiotensin-converting-enzyme inhibitors provide renal protection in patients with mild-to-moderate renal insufficiency (serum creatinine level, 3.0 mg per deciliter or less). We assessed the efficacy and safety of benazepril in patients without diabetes who had advanced renal insufficiency. METHODS We enrolled 422 patients in a randomized,(More)
Prior studies have revealed associations of current lead exposure (blood lead) and past lead exposure (bone lead) with risks of hypertension and elevated blood pressure. The authors examined the effects of blood and bone lead on hypertension and elevated blood pressure in the third trimester and postpartum among 1,006 women enrolled in Los Angeles prenatal(More)
It has become apparent that hypoxia and hypoxia-inducible factor-1 (HIF-1) activation have the potential of modulating the activity of major epithelial-mesenchymal transition (EMT)-triggering pathways by regulating the expression and activity levels of major transcriptional repressors. The aim of our study was to elucidate the role of HIF-1α and HIF-2α, and(More)
A hypoxic microenvironment plays a critical role in the development and progression of tumors. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their polarity and are converted to a mesenchymal phenotype, which is regarded as a critical event in morphogenetic changes during embryonic development, wound healing, and(More)
Content Delivery Network (CDN) and Hypertext Transfer Protocol Secure (HTTPS) are two popular but independent web technologies, each of which has been well studied individually and independently. This paper provides a systematic study on how these two work together. We examined 20 popular CDN providers and 10,721 of their customer web sites using HTTPS. Our(More)
Stock time series segmentation is one of the fundamental components in stock time series data mining. And the segmentation is often used for the trend analysis. In this paper, a new stock time series segmentation algorithm is proposed based on PIP(Perceptually Important Point) approach. This proposed segmentation method contributes to containing both the(More)
Pattern matching in stock time series is an active research area in data mining. We propose a new real-time hybrid pattern-matching algorithm in this paper. The algorithm is based on the Spearman’s rank correlation, rule sets and sliding window. The concept of sliding windows enables patterns matching to be performed only based on subsequence of stock data(More)
Cholinergic agents elicit prominent smooth muscle contractions via stimulation of muscarinic receptors that comprise five distinct subtypes (M1-M5). Although such contractions are important for autonomic organs, the role of each subtype has not been characterized precisely because of the poor selectivity of the currently available muscarinic ligands. Here,(More)
The Renoprotection of Optimal Antiproteinuric Doses (ROAD) study was performed to determine whether titration of benazepril or losartan to optimal antiproteinuric doses would safely improve the renal outcome in chronic renal insufficiency. A total of 360 patients who did not have diabetes and had proteinuria and chronic renal insufficiency were randomly(More)
Retinal neovascularization (NV) occurs in various ocular disorders including proliferative diabetic retinopathy, retinopathy of prematurity and secondary neovascular glaucoma, which often result in blindness. Vascular endothelial growth factor (VEGF) is an essential growth factor for angiogenesis, and is particularly regulated by hypoxia inducible(More)