Learn More
Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is the signature event in pancreatic ductal adenocarcinoma (PDAC), serving a critical role in tumor initiation. Here, an inducible Kras(G12D)-driven PDAC mouse model establishes that advanced PDAC remains(More)
Demographic information plays an important role in personalized web applications. However, it is usually not easy to obtain this kind of personal data such as age and gender. In this paper, we made a first approach to predict users' gender and age from their Web browsing behaviors, in which the Webpage view information is treated as a hidden variable to(More)
We find that on average an announcement of rising unemployment is " good news " for stocks during economic expansions and " bad news " during economic contractions. Unemployment news bundles three types of primitive information relevant for valuing stocks: information about future interest rates, equity risk premium, and corporate earnings and dividends.(More)
In this paper we study optimization problems with second-order stochastic dominance constraints. This class of problems allows for the modeling of optimization problems where a risk-averse decision maker wants to ensure that the solution produced by the model dominates certain benchmarks. Here we deal with the case of multi-variate stochastic dominance(More)
Most traditional text clustering methods are based on "bag of words" (<i>BOW</i>) representation based on frequency statistics in a set of documents. <i>BOW</i>, however, ignores the important information on the semantic relationships between <i>key</i> terms. To overcome this problem, several methods have been proposed to enrich text representation with(More)
Understanding the intent behind a user's query can help search engine to automatically route the query to some corresponding vertical search engines to obtain particularly relevant contents, thus, greatly improving user satisfaction. There are three major challenges to the query intent classification problem: (1) Intent representation; (2) Domain coverage(More)
This paper presents and studies models for multi-criterion budget allocation problems under uncertainty. The proposed models incorporate uncertainties in decision maker's weights using a robust weighted sum approach. The risk averseness of the decision maker in satisfying random risk related constraints is ensured by using stochastic dominance. A sample(More)
To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the setting of telomere dysfunction enabled(More)
Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼ 7 mo after diagnosis. Understanding the molecular architecture of this residual population is critical for the development of successful(More)