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A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus*
TLDR
The identification of a novel intronless SUMO gene, SUMO-4, that encodes a 95-amino acid protein having an 86% amino acid homology withsumO-2, which is associated with type I diabetes mellitus susceptibility in families and suggests that it may be involved in the pathogenesis of type Iabetes. Expand
A ROR1-HER3-LncRNA signaling axis modulates the Hippo-YAP pathway to regulate bone metastasis
TLDR
The data provide insights into the mechanistic regulation and linkage of the ROR1–HER3 and Hippo–YAP pathway in a cancer-specific context, and also imply valuable therapeutic targets for bone metastasis and possible therapy-resistant tumours. Expand
The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis
TLDR
MiR-224 expression in primary CRC, alone or combined with its targets, may have prognostic value for survival of patients with CRC and promotes CRC metastasis, at least in part, through the regulation of SMAD4. Expand
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis
TLDR
It is determined that expression of a long noncoding RNA (lncRNA) that is named lncRNA associated with BCBM (Lnc-BM) is prognostic of the progression of brain metastasis in breast cancer patients and suggests targeting Lnc- BM as a potential strategy for fighting this difficult disease. Expand
Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer
TLDR
Antiandrogen and PARP inhibitor combination therapy may be effective for CRPC patients and suggests that pharmaceutically inducing BRCAness may expand the clinical use of PARP inhibitors to other tumor types. Expand
Targeting Constitutively Activated β1 Integrins Inhibits Prostate Cancer Metastasis
TLDR
Levels of β1 integrins and integrin-induced autophosphorylation of FAK are increased in prostate cancer cells in primary prostate cancer and lymph node metastases, suggesting thatβ1 integrin activation occurs in metastatic progression of prostate cancer. Expand
Ligand‐independent activation of MET through IGF‐1/IGF‐1R signaling
TLDR
It is demonstrated that IGF‐1‐induced delayed MET activation occurs in multiple cell lines which express both the receptors, suggesting that IGF-1R‐mediated MET activation may contribute to tumorigenic properties of multiple cancer types when both growth factor receptors are expressed. Expand
RSK Promotes Prostate Cancer Progression in Bone through ING3, CKAP2, and PTK6-Mediated Cell Survival
TLDR
Mechanistic studies showed that RSK regulates anchorage-independent growth through transcriptional regulation of factors that modulate cell survival, including ING3, CKAP2, and PTK6, which provides strong evidence that R SK is an important driver in prostate cancer progression in bone. Expand
Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis
TLDR
Cdk5-mediated phosphorylation of talin1 leading to β1 integrin activation is a novel mechanism that increases metastatic potential of PCa cells, and Immunohistochemical staining demonstrated that talin S425 phosphorylated is significantly increased in human bone metastases when compared with normal tissues, primary tumors or lymph node metastases. Expand
A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
TLDR
Findings provide direct evidence that AtYY1 is a novel negative regulator of the ABA response network and that the ABI4-AtYY1-ABR1 regulatory pathway may fine-tune ABA-responsive gene expression in Arabidopsis. Expand
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