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Comparative genomics and transcriptome analysis of Aspergillus niger and metabolic engineering for citrate production
TLDR
Comparative genomics and transcriptome analysis of citrate-producing strains revealed that the transcription levels of 479 genes changed between the cell growth stage and the citrate synthesis stage, and two cytosol ATP-citrate lyases were up-regulated and may coordinate with the alternative oxidases in the alternative respiratory pathway for energy balance. Expand
High-yield novel leech hyaluronidase to expedite the preparation of specific hyaluronan oligomers
TLDR
Analysis of the hydrolytic process suggested that this novel enzyme adopts a nonprocessive endolytic mode, yielding a narrow-spectrum of specific HA oligosaccharides with different incubation times, suggesting large-scale production of this novel leech HAase will not only greatly promote medical applications but also facilitate the enzymatic production of specific haemorrhages. Expand
AtMGT7: An Arabidopsis gene encoding a low-affinity magnesium transporter.
TLDR
This study has identified from a higher plant the first low-affinity Mg(2+) transporter encoded by a gene with alternatively spliced transcripts that produce proteins with distinct functions. Expand
Pathway engineering of Propionibacterium jensenii for improved production of propionic acid
TLDR
Propionic acid production in P. jensenii with ppc overexpression as well as ldh deletion was investigated, which resulted in further increases in PA titer to 34.93 ± 2.99 g·L−1 in a fed-batch culture. Expand
OsAREB1, an ABRE-binding protein responding to ABA and glucose, has multiple functions in Arabidopsis.
TLDR
OsAREB1 may function as a positive regulator in drought/heat stresses response, but a negative regulator in flowering time in Arabidopsis, according to the dates. Expand
Genome Sequencing of the Pyruvate-producing Strain Candida glabrata CCTCC M202019 and Genomic Comparison with Strain CBS138
TLDR
Analysis of the C. glabrata CCTCC M202019 genome sequence provides useful insights into its genetic context, physical characteristics, and potential metabolic capacity. Expand
Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli
TLDR
It is demonstrated that ALA dehydratase (HemB) encoded by hemB is feedback inhibited by the downstream intermediate protoporphyrinogen IX, and has great potential to be scaled-up for microbial production of ALA. Expand
Small RNA regulators in bacteria: powerful tools for metabolic engineering and synthetic biology
TLDR
This review describes recent achievements in the identification, characterization, and application of small RNAs and gives particular attention to advances in the design and synthesis of novel sRNAs and riboswitches for metabolic engineering. Expand
One-step biosynthesis of α-ketoisocaproate from l-leucine by an Escherichia coli whole-cell biocatalyst expressing an l-amino acid deaminase from Proteus vulgaris
TLDR
An effective process for the biotechnological production of α-ketoisocaproate that is more environmentally friendly than the traditional petrochemical synthesis approach is developed. Expand
Identification and application of keto acids transporters in Yarrowia lipolytica
TLDR
Systematic identification of keto acids transporters would provide clues to further improve the accumulation of specific organic acids with higher efficiency in eukaryotic microorganisms. Expand
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