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We have developed a novel tactile presentation system for assessing and training cognitive function on tactile senses. The device is operational in magnetic resonance imaging (MRI) environment and capable of investigating the underlying neural mechanisms of tactile pattern discrimination. The primary components of the system include a finger movement(More)
The scandal of melamine-contamination has not been quite blown out, since the toxicity of melamine continues to raise concerns for public health. It has been well known that fetus and infant periods play the most important roles in brain development, whereas little has been done on the harmful effects of melamine on the center nervous system (CNS) of(More)
BACKGROUND Bexarotene, a retinoid X receptor agonist, has been shown to reverse neurodegeneration in mouse models of Alzheimer's disease (AD), accompanied by a decreased level of amyloid-β (Aβ), which is a hallmark of AD. However, the mechanism underlying this therapeutic effect may involve enhancing the sensitivity to insulin. OBJECTIVE This study was to(More)
Fitts' law robustly predicts the time required to move rapidly to a target. However, it is unclear whether Fitts' law holds for visually guided actions under visually restricted conditions. We tested whether Fitts' law applies under various conditions of visual restriction and compared pointing movements in each condition. Ten healthy participants performed(More)
This study was to investigate the neurotoxicity of multi-walled carbon nanotube (MWCNT) by measuring neuronal excitability in rat hippocampal neurons and exploring the underlying mechanism. Whole cell patch-clamp technique was used. Action potential properties and the pattern of repetitive firing rate were assessed. Our data showed that spike half-width and(More)
The podocyte is a remarkable cell type, which encases the capillaries of the kidney glomerulus. Podocytes are of keen interests because of their key roles in kidney development and disease. Large-conductance Ca2+-activated K+ channels (BKCa channels) are important ion channels located in podocytes and play the essential role in regulating calcium(More)
Maternal nutrition plays a critical role in physical growth and neurobehavior of offspring. The aim of this study was to assess the nature of maternal undernutrition on the physical growth and neurobehavior of newborn male and female rat pups. To attain this aim, a model of maternal 50% food restriction (FR50) was induced in Wistar rats. After parturition,(More)
Intra-active touch (IAT) is a process that involves a body part doing the touching (active touch [AT]) and another body part being touched (passive touch [PT]) simultaneously. The brain representation related to IAT is still unclear. A total of 23 subjects carried out angle discrimination under PT, AT and IAT conditions with functional magnetic resonance(More)
Increasing of peroxynitrite (ONOO(-)) production during ischemia in the immature brain was considered to be associated with impaired cognitive function. GABAergic synapses played an important role in memory formation including the induction of long-term potentiation (LTP) and long-term depression (LTD) in hippocampus. In the present study, we examined the(More)
BACKGROUND Photophobia and phonophobia are the most prominent symptoms in patients with migraine without aura. Hypersensitivity to visual stimuli can lead to greater hypersensitivity to auditory stimuli, which suggests that the interaction between visual and auditory stimuli may play an important role in the pathogenesis of migraine. However, audiovisual(More)