Learn More
Megakaryocytes are unique mammalian cells that undergo polyploidization (endomitosis) during differentiation, leading to an increase in cell size and protein production that precedes platelet production. Recent evidence demonstrates that endomitosis is a consequence of a late failure in cytokinesis associated with a contractile ring defect. Here we show(More)
Megakaryocytes are highly specialized precursor cells that produce platelets via cytoplasmic extensions called proplatelets. Proplatelet formation (PPF) requires profound changes in microtubule and actin organization. In this work, we demonstrated that DIAPH1 (mDia1), a mammalian homolog of Drosophila diaphanous that works as an effector of the small GTPase(More)
Megakaryocyte is the naturally polyploid cell that gives rise to platelets. Polyploidization occurs by endomitosis, a process corresponding to a late failure of cytokinesis with a backward movement of the daughter cells. Generally, a pure defect in cytokinesis produces a multinucleated cell, but megakaryocytes are characterized by a single polylobulated(More)
Endomitosis is a unique megakaryocyte (MK) differentiation process that is the consequence of a late cytokinesis failure associated with a contractile ring defect. Evidence from in vitro studies has revealed the distinct roles of 2 nonmuscle myosin IIs (NMIIs) on MK endomitosis: only NMII-B (MYH10), but not NMII-A (MYH9), is localized in the MK contractile(More)
The paper presents City Flow, an urban traffic visualization prototype based on real post streams captured from Sina Weibo, the most popular social networking site in China. With the increasingly pervasive use of online social networks in China, these new channels attract more users than conventional social media. People use them to seek comments and points(More)
TP53 also known as p53 is a tumor suppressor gene mutated in a variety of cancers. P53 is involved in cell cycle, apoptosis and DNA repair mechanisms and is thus tightly controlled by many regulators. Recently, strategies to treat cancer have focused on the development of MDM2 antagonists to induce p53 stabilization and restore cell death in p53 non-mutated(More)
The paper presents a visualization prototype that tackles the issue of public emotion. It emphasizes the exploration process in the aim of creating reflections for the viewer to observe the whole social context as well as individual perspectives. Urban traffic conversation on SNS (Social Networking Site) is our current interest. The prototype we present is(More)
We extend the Chebyshev-Legendre spectral method to multi-domain case for solving the two-dimensional vorticity equations. The schemes are formulated in Legendre-Galerkinmethod while the nonlinear term is collocated at Chebyshev-Gauss collocation points. We introduce proper basis functions in order that the matrix of algebraic system is sparse. The(More)
  • 1