Jiajia Feng

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UNLABELLED Mechanisms to maintain genomic integrity are essential for cells to remain viable. Not surprisingly, disruption of key DNA damage response pathway factors, such as ataxia telangiectasia-mutated (ATM)/ataxia telangiectasia and RAD3-related (ATR) results in loss of genomic integrity. Here, a synthetic lethal siRNA-screening approach not only(More)
Keyword extraction is to automatically extract keywords that capture the main topic discussed in a given document. In this paper, a new keyword extraction algorithm based on sequential patterns is proposed. By preprocessing, a document is represented as sequences of words where a sequential pattern mining algorithm is applied on, and important sequential(More)
Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the discovery of therapeutic targets for counteracting tumor suppressor gene loss is needed. To identify(More)
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