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Comments are welcome, but please do not quote without t h e a u t h ors' permission. Abstract In this paper we consider the problem of making inference on a structural parameter in instrumental variables regression when the instruments are only weakly correlated with t h e e n dogenous explanatory variables. Adopting a local-to-zero assumption as in Staiger(More)
We consider a deterministically trending dynamic time series model in which m ultiple structural changes in level, trend and error variance are modeled explicitly and the number but not the timing of the changes are known. Estimation of the model is made possible by the use of the Gibbs sampler. The determination of the number of structural breaks and the(More)
PURPOSE Accurate segmentation of lungs with severe interstitial lung disease (ILD) in thoracic computed tomography (CT) is an important and difficult task in the development of computer-aided diagnosis (CAD) systems. Therefore, we developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD in multidetector CT(More)
Glioblastomas respond differently to all-trans retinoic acid (RA) for unknown reasons. Because CRABP-II and FABP5 mediate RA intracellular signaling respectively and lead to distinct biological consequences, their expression patterns in different grades of astrocytomas and the glioblastoma cells lines LN18, LN428 and U251 were examined to identify potential(More)
Automated segmenting and labeling of individual brain anatomical regions, in MRI are challenging, due to the issue of individual structural variability. Although atlas-based segmentation has shown its potential for both tissue and structure segmentation, due to the inherent natural variability as well as disease-related changes in MR appearance, a single(More)
MOTIVATION The 3D structure of the genome plays a critical role in regulating gene expression. Recent progress in mapping technologies for chromatin interactions has led to a rapid increase in this kind of interaction data. This trend will continue as research in this burgeoning field intensifies. RESULTS We describe the 4DGenome database that stores(More)
The VOLCANO'09 Challenge invited participants to evaluate the change in size of pulmonary nodules in CT images; the challenge data set consisted of 50 pairs of CT scans each scan containing a single nodule. This is the first challenge for CAD methods on pulmonary nodules in which size change rather than volume estimation is the primary endpoint. Responses(More)
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder in which the loss of dystrophin causes progressive degeneration of skeletal and cardiac muscle. Potential therapies that carry substantial risk, such as gene- and cell-based approaches, must first be tested in animal models, notably the mdx mouse and several dystrophin-deficient breeds of(More)
Relaxin is a prototype of the relaxin family peptide hormones and plays important biological functions by binding and activating the G protein-coupled receptor RXFP1. To study their interactions, in the present work, we applied the newly developed bioluminescent ligand–receptor binding assay to the relaxin-RXFP1 system. First, a fully active easily labeled(More)
In this study, we investigated whether fully implantable CES with low current density and varying low-frequency burst impulse train enhances functional recovery and promotes brain remodeling in both the ipsilesional and contralesional cortex. Adult rats received occlusion of the right middle cerebral artery for 120min. One week after ischemia, electrodes(More)