Jiagen Sheng

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Treatment of skeletal defects secondary to osteomyelitis is a challenging problem. The purpose of this study was to present our experience of the use of free vascularised fibular grafts to treat such defects. Ten patients with a mean age of 31 years (range 16–50 years) and a skeletal defect with a mean length of 9.5 cm (range 6–17 cm) were managed with a(More)
OBJECTIVE To investigate the effectiveness of free vascularized fibula grafting with unilateral fibula as donor in treatment of bilateral avascular necrosis of femoral head (ANFH). METHODS Between June 2007 and January 2008, 14 patients with bilateral ANFH were treated with free vascularized fibula grafting with unilateral fibula as donor. There were 12(More)
The aim of this study was to compare the safety and efficacy of OsteoSet®2 DBM with autologous cancellous bone in free vascularised fibular grafting for the treatment of large osteonecrotic lesions of the femoral head. Twenty-four patients (30 hips) with large osteonecrotic lesions of the femoral head (stage IIC in six hips, stage IIIC in 14, and stage IVC(More)
Reconstruction of large skeletal defects secondary to osteomyelitis or open fracture is a challenging problem. The purpose of this study was to evaluate the results of using free vascularized fibular graft (FVFG) combined with locking plate in the treatment of large skeletal defects from open fracture and infection. Ten patients with a mean age of 34 years(More)
OBJECTIVE To assess the effect of basic fibroblast growth factor (bFGF) and 5-fluorouracil (5-FU) applied topically on the tendon adhesion and the healing process after the flexor tendon repair in Leghorn chickens. METHODS Ninety male Leghorn chickens (weighing 3.0-3.5 kg) were randomly divided into 3 groups, with 30 chickens in each group. The flexor(More)
High levels of pro-inflammatory cytokines in leukocyte- and platelet-rich plasma (L-PRP) may activate the nuclear factor κB (NF-κB) pathway to counter the beneficial effect of the growth factors on bone regeneration. However, to date, no relevant studies have substantiated this. L-PRP and pure platelet-rich plasma (P-PRP) were isolated. The in vitro effects(More)
OBJECTIVE To explore the effects of exogenous basic fibroblast growth factor (bFGF) on in-sheathed tendon healing and adhesion formation. METHODS Ninety Leghorn chickens were randomly divided into 3 groups (groups A, B and C), 30 animals for each group, and the right third digitorum longus tendon of the chicken was transected to make defect models. In(More)
The content and searching method of knowledge base are lack of the consideration of user requirements, it is difficult for the user to select the knowledge satisfy with the user requirements from candidate set of a lot of knowledge items. So, we propose a new knowledge recommend system based on user model. According to the corresponding relationship between(More)
While it has been proved that centrifugal conditions for pure platelet-rich plasma (P-PRP) preparation influence the cellular composition of P-PRP obtained, the optimal centrifugal conditions to prepare P-PRP have not yet been identified. In the present study, platelet-containing plasma (PCP) was prepared with the first-spin of different double-spin methods(More)
OBJECTIVE To review the relationship between heritable hypercoagulable state (HHCS) and avascular necrosis of femoral head (ANFH). METHODS The latest original articles about the relationship between HHCS and ANFH were extensively reviewed. RESULTS Several genetic mutations which could cause HHCS, such as thrombophilic factor V G1691A gene, thrombophilic(More)