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OBJECTIVE Apoptotic cell death is an important factor influencing the prognosis after traumatic brain injury (TBI). Akt/GSK-3beta/beta-catenin signaling plays a critical role in the apoptosis of neurons in several models of neurodegeneration. The goal of this study was to determine if the mechanism of cell survival mediated by the(More)
—This paper proposes and analyzes the performance of a simple frequency-agile CSMA MAC protocol. In this MAC, a node carrier-senses multiple frequency channels simultaneously, and it takes the first opportunity to transmit on any one of the channels when allowed by the CSMA backoff mechanism. We show that the frequency-agile MAC can effectively 1) boost(More)
BACKGROUND Adipocyte fatty acid-binding protein (A-FABP) is traditionally thought to be a cytosolic fatty acid chaperone expressed in adipocytes. Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to(More)
BACKGROUND Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies. METHODS We used real-time PCR and in-house immunoassays to quantify the mRNA and serum(More)
Network Capacity, which is limited by interference between simultaneous transmissions of neighboring links, is a fundamental performance metric for wireless ad hoc networks. Ref. [1] showed that the capacity of wireless ad hoc networks with omnidirectional antennae does not scale well as the node density increases. Other related work ([2], [3], [4], etc.)(More)
OBJECTIVE Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein that has recently been implicated in the regulation of angiogenesis and metastasis. This study aimed to investigate the structural and cellular basis underlying the biological actions of Angptl4. METHODS AND RESULTS Circulating Angptl4 was proteolytically cleaved into NH2-terminal(More)
—Most prior studies on wireless spatial-reuse TDMA (STDMA) link scheduling for throughput optimization deal with the situation where instantaneous channel state information (CSI) is available. Under fast fading, however, the channel may change too quickly for the scheduler to track the instantaneous CSI. In this paper, instead of the instantaneous CSI, the(More)
Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D. However, the pathological roles of neutrophils in the development of T1D remain unknown. Here we show that circulating protein levels and enzymatic activities of neutrophil(More)
Most current wireless IEEE 802.11 networks rely on a power-threshold based carrier-sensing multi-access (CSMA) mechanism to prevent packet collisions, in which a transmitter permits its transmission only if the locally measured aggregate interference power from all existing transmissions is below a prespecified power-sensing threshold. However, such a(More)
BACKGROUND Previous work, by us and others, has shown that mammalian galectins-1 have a growth-inhibitory activity for mammalian cells which is apparently independent of their beta-galactoside binding site. RESULTS We have made recombinant human galectin-1 as a bacterial fusion protein with an N-terminal hexahistidine tag. This protein displays both(More)