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BACKGROUND The authors conducted a meta-analysis to evaluate the effectiveness and safety of negative-pressure wound therapy for diabetic foot ulcers. METHODS PubMed, EMBASE, and the Cochrane Library were searched to identify relevant studies published up to February of 2013. All randomized controlled trials comparing negative-pressure wound therapy and(More)
OBJECTIVE To investigate the differential expression of different types of Smads in keloids, normal scars and normal skins and its possible clinicopathological significance. METHODS RT-PCR and Western blot methods were used to examine the expression of Smads mRNA and proteins level in 10 cases of keloid, in 10 cases of normal scar and in 10 cases of(More)
OBJECTIVE To investigate and search correlative proteins of keloid by comparing the results of differential proteomic analysis between keloid and normal skin. METHODS From January 2010 to June 2010 two-dimensional gel electrophoresis was used to define patterns of protein expression in keloid skin from 8 patients and matched normal skin from 3 patients.(More)
BACKGROUND Although escharectomy and full-thickness skin autografting have been widely used to treat deep facial burns, the clinical outcomes remain unacceptable. Composite razor-thin skin grafting over acellular dermal matrix scaffold has been used successfully in repairing burns of the trunk and limbs, but its use in covering deep facial burns has rarely(More)
OBJECTIVE To study the in vitro cleavage activity and the reaction conditions of the hammerhead ribozymes for the second exons of pro alpha 1I and III collagen genes, and observe the effect of the two ribozymes on collagen synthesis by the fibroblasts in scar tissue. METHODS The fragments of the second exons of pro alpha 1I and III collagen genes were(More)
OBJECTIVE To evaluate the effect of mixed composite skin graft on the deep partial thickness burn wounds after tangential excision in burn patients. METHODS Tangential excision was performed in 30 extremities of 23 burn patients within 3 postburn days (PBDs). Then large pieces of homologous acellular dermal matrix were grafted onto the superficial fascia(More)
Transforming growth factor-β (TGF-β)/Smad signaling plays a key role in excessive fibrosis and keloid formations. Smad7 is a negative feedback regulator that prevents activation of TGF-β/Smad signaling. However, the regulatory mechanism for Smad7 in the keloid pathogenic process remains elusive. Here, we show that expression of TIEG1 is markedly higher in(More)
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