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Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
TLDR
Strong evidence of associations between PCOS and three loci is identified and follow-up studies of the candidate genes in these regions are recommended, providing new insight into the pathogenesis of PCOS. Expand
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
TLDR
Eight new PCOS association signals are identified that show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D) and other candidate genes were related to calcium signaling and endocytosis. Expand
Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome.
TLDR
Among infertile women with the polycystic ovary syndrome, frozen-embryo transfer was associated with a higher rate of live birth, a lower risk of the ovarian hyperstimulation syndrome, and a higher risk of preeclampsia after the first transfer than was fresh-embyo transfer. Expand
Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis.
TLDR
Children conceived by IVF and/or ICSI are at significantly increased risk for birth defects, and there is no risk difference between children conceived byIVF and-or I CSI. Expand
Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells
TLDR
The results suggest that BPA may interrupt ovarian steroidogenesis by altering the steroidogenic enzymes. Expand
Characterization of Serum MicroRNAs Profile of PCOS and Identification of Novel Non-Invasive Biomarkers
TLDR
Serum miRNAs are differentially expressed between PCOS patients and controls, and bioinformatics analysis indicated that the predicted targets function of the three miRN as mainly involved in the metastasis, cell cycle, apoptosis and endocrine. Expand
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia
TLDR
Findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men. Expand
Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women.
TLDR
The findings have shown genuine heterogeneity, stratified on the basis of both clinical findings and genotypes, as significant metabolic disturbances may emerge later in life in PCOS patients of Han Chinese descent. Expand
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
TLDR
A genome-wide association study of Han Chinese subjects to identify genetic susceptibility loci for nonobstructive azoospermia (NOA) detected variants at human leukocyte antigen (HLA) regions that were independently associated with NOA. Expand
Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus
TLDR
The differences of placenta ultrastructure are likely responsible for the impairment of placental barrier and function in GDM. Expand
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