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The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers
TLDR
Results suggest psiTPTE22‐HERV is regulated epigenetically by DNA methylation, which paved the way for further study on an interesting HERV‐related human‐specific gene, which is silenced in cancers byDNA methylation.
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Combination of small interfering RNAs mediates greater inhibition of human hepatitis B virus replication and antigen expression.
TLDR
The results showed that the combination of siRNAs targeting various regions could inhibit HBV replication and antigen expression in a more efficient way than the use of single siRNA at the same final concentration.
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Identification of a novel human endogenous retrovirus and promoter activity of its 5' U3.
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Apoptosis induction with polo-like kinase-1 antisense phosphorothioate oligodeoxynucleotide of colon cancer cell line SW480.
TLDR
PLK1 ASODN can induce apoptosis of human colon cancer cell line SW480 and is induced in a time- and dose-dependent manner, according to Apoptosis index (AI).
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Evaluation of ST13 gene expression in colorectal cancer patients
TLDR
The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa, but there were no significant differences in the expression of ST13 as compared with different Dukes’ stage, tumor differentiation grade, invasion depth, lymph node metastasis and disease-specific survival.
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[Knockdown of PLK1 mRNA by special siRNA].
To study knockdown effect of small interfering RNA (siRNA) to PLK1 (Polo-like kinase 1) mRNA in colorectal cancer cell line SW480 and its mitosis and growth was changed. Ten special siRNA molecules…
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Identification and detection of a novel human endogenous retrovirus-related gene, and structural characterization of its related elements
TLDR
The results presented here recommend further investigation into a potentially functional HERV-H-related ncRNA, which lacks protein-coding capacity and may belong to the emerging class of noncoding RNAs (ncRNAs).
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[Deletion of the env region in HERV-H-X gene and its expression in colon cancer].
TLDR
HerV-H-X is highly expressed in colon cancer, but its up-regulation is not related to env gene as it lacks an env ORF.
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[Inhibition of hepatitis B virus by combined siRNAs in vitro].
TLDR
Results showed that HBV replication could be inhibited by treatment with these siRNAs in a dose-dependent manner, providing solid evidence for developing new approaches in HBV treatment with combinedSiRNAs.
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Hsa_circ_0013731 Mediated by E2F1 Inhibits Ferroptosis in Hepatocellular Carcinoma Cells by Sponging miR-877-3p and Targeting SLC7A11
TLDR
The data reveal that circ_0013731 mediated by E2F1 facilitates cell growth and suppressed the ferroptosis via miR-877-3p/ SLC7A11 axis in hepatocellular carcinoma.
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