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HERG K+ channel expression in CD34+/CD38−/CD123high cells and primary leukemia cells and analysis of its regulation in leukemia cells
TLDR
It is reported that herg was expressed in CD34+/CD38−/CD123high LSCs but not expressed in normal bone marrow CD34+, and the expression of herg mRNA was not associated with the clinical and cytogenetic feature of leukemia. Expand
The insulin-like growth factor-1 receptor kinase inhibitor, NVP-ADW742, suppresses survival and resistance to chemotherapy in acute myeloid leukemia cells.
TLDR
It is demonstrated that NVP-ADW742 could synergize with Ara-C to induce the kill in a subset of drug-resistant AML specimens and suggested that IGF-lR targeting might be therapeutically beneficial for some AML patients. Expand
[Methylation status of JunB and CDH13 gene promoter in CD34(+)CD38(-) chronic myelogenous leukemia cells].
TLDR
It is concluded that the high methylation of JunB and CDH13 gene promoter occurs in CD34(+)CD38(-) cells of CML patients, their mRNA expression level is significantly lower, thus the methylation is probably plays a role in the pathogenesis of C ML and may have clinical significance in predicting prognosis. Expand
[Expression and role of toll-like receptors in U937 cells].
TLDR
It is concluded that TLRs including TLR 1 - 9 express on U937 cells and TLR 8 agonist ssRNA40/LyoVec may be able to inhibit the growth of U 937 cells, arrest the cells in G(0)/G(1) phase, but have no effect of promoting apoptosis. Expand
Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells
TLDR
TCA exerts cytotoxic effects on human leukemia K562 cells by inducing apoptosis and synergizing the cytotoxicity of CIK cells against K562 Cells, which are beneficial to the treatment of leukemia, even in the patients who have received hematopoietic stem cells transplantation (HSCT). Expand
Relevance of immunophenotypes to prognostic subgroups of age, WBC, platelet count, and cytogenetics in de novo acute myeloid leukemia
TLDR
Relevance of immunophenotypes to prognostic subgroups of age, WBC, platelet count, and cytogenetics in de novo acute myeloid leukemia in APMIS 2010 is studied. Expand
Expression and fuactional role of HERG1, K+ channels in leukemic cells and leukemic stem cells
SummaryIn order to investigate the expression and functional role of HERG1 K+ channels in leukemic cells and leukemic stem cells (LSCs), RT-PCR was used to detect the HERG1 K− channels expression inExpand
Expression and functional role of HERG1, K+ channels in leukemic cells and leukemic stem cells.
TLDR
HerG1 K+ channels may also have oncogenic potential and may be a biomarker for diagnosis of leukemia and a novel potential pharmacological target for leukemia therapy. Expand
[Differential expression profiles of MicroRNA during the development of human cord blood CD34(+)CD38(-) cells to CD34(+)CD38(+) cells].
TLDR
It is concluded that the hematopoietic "stemness" miRNAs play important roles in normal hematOPoiesis: miRNA expression profiles of hematoplastic stem cell/progenitors --> their gene expression profiles --> their self-renewal and lineage-commmitted differeniation. Expand
Deregulated expression of Cdc6 as BCR/ABL-dependent survival factor in chronic myeloid leukemia cells
TLDR
It is demonstrated that cell division cycle protein 6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia cells and can be regulated by BCR/ABL signal transduction through downstream phosphoinositide 3-kinase/Akt and Janus kinase/signal transducer and activator of transcription pathways. Expand
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