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Copper-free sonogashira coupling reaction with PdCl2 in water under aerobic conditions.
A mild protocol for the copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed and good to excellent yields are reported. Expand
Concise synthesis of isoquinoline via the Ugi and Heck reactions.
[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction,Expand
Rapid biomimetic total synthesis of (±)-rossinone B.
A biomimetic total synthesis of (±)-rossinone B has been achieved through a highly efficient strategy featuring a series of rationally designed reactions, including a one-pot allylicExpand
Diastereoselective total synthesis of (±)-schindilactone A.
These efforts on the development of synthetic methods and a strategy centered on the construction of the polycyclic ring system that allowed the first total synthesis of ( )-schindilactone A are reported, which opens a pathway for the syntheses of other compounds related to schindilACTone A, as well as their derivatives and analogues. Expand
Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent.
The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent and was successfully applied to the synthesis of flavones. Expand
Direct imidation to construct 1H-benzo[d]imidazole through Pd(II)-catalyzed C-H activation promoted by thiourea.
A new method to construct 1H-benzo[d]imidazole through Pd-catalyzed intramolecular C N formation is reported, in which not only the substrate scope was widely extended, but also thiourea was introduced for the first time as an additive to promote the efficiency of the Pd catalysis for the direct C H transformation. Expand
Tetramethyl thiourea/Co2(CO)8-catalyzed Pauson-Khand reaction under balloon pressure of CO.
A Pauson-Khand type of conversion of enynes to bicyclic cyclopentenones employing the commercially available Co2(CO)8 and tetramethylthiourea (TMTU) as catalysts is described. This method allows aExpand
A Novel Thiourea Ligand Applied in the Pd‐Catalyzed Heck, Suzuki and Suzuki Carbonylative Reactions
A novel C2 symmetrical and sterically bulky thiourea ligand 1 has been successfully applied to Heck, Suzuki and Suzuki-type carbonylative coupling reactions under aerobic conditions. Since theExpand
Diastereoselective total synthesis of (±)-schindilactone A, Part 1: Construction of the ABC and FGH ring systems and initial attempts to construct the CDEF ring system.
First-generation synthetic strategies for the diastereoselective total synthesis of schindilactone A (1) are presented and methods for the synthesis of the ABC, FGH, and CDEF moieties are explored.Expand
Asymmetric Total Synthesis of Lancifodilactone G Acetate.
Asymmetric total synthesis of structurally intriguing and highly oxygenated lancifodilactone G acetate (7) has been achieved for the first time in 28 steps from a cheap commodity chemical,Expand