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The worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis threatens to make this disease incurable. Drug resistance mechanisms are only partially understood, and whether the current understanding of the genetic basis of drug resistance in M. tuberculosis is sufficiently comprehensive remains unclear. Here we(More)
As Web services become more prevalent, the need to ensure their quality increases. This paper explores the criteria of reliability of Web services-oriented systems, and discusses how to design and generate test cases to conduct tests over Web services. A prototype system is constructed to test the effectiveness and efficiency of our algorithms. The(More)
BACKGROUND Gallbladder cancer (GC) is considered a relatively rare malignancy with extensively poor prognosis. To guide clinicians in selecting treatment options for GC patients, reliable markers predictive of poor clinical outcome are desirable. This study analyzed the correlation of NF-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and multidrug(More)
E3 ubiquitin ligases are important in both innate and adaptive immunity. Here we report that Nrdp1, an E3 ubiquitin ligase, inhibited the production of proinflammatory cytokines but increased interferon-beta production in Toll-like receptor-triggered macrophages by suppressing adaptor MyD88-dependent activation of transcription factors NF-kappaB and AP-1(More)
OBJECTIVE To analyze the causes of the complications associated with the pedicle screw fixation during and after operation, as well as the methods for prevention and treatment. METHODS From January 1988 to December 1999, 475 patients who underwent pedicle screw fixation for various spinal disorders were reviewed retrospectively with statistical analysis.(More)
V arious IT professionals have, at one time or another, erroneously used the terms software as a service (SaaS) and service-oriented architecture (SOA) interchangeably. At best, this faulty practice creates confusion; at its worst, it can lead to poor designs. Our goal, therefore, is to clarify the meaning of these two often used and abused terms. Briefly(More)
Acyl-CoA dehydrogenases (ACADs) are a family of mitochondrial enzymes catalyzing the initial rate-limiting step in the beta-oxidation of fatty acyl-CoA. The reaction provides main source of energy for human heart and skeletal muscle. Eight human ACADs have been described. Deficiency of these enzymes, especially very long-chain acyl-CoA dehydrogenase(More)
A web service is a programmable web application accessible using standard Internet protocols. A threelayer architecture has been suggested for web services: service providers, service brokers, and service requesters. We propose in this paper a SOAP-oriented componentbased framework to support device-independent multimedia web services. Two intelligent(More)
Mashup has emeraged as a promising way to allow developers to compose existed APIs (services) to create new or value-added services. With the rapid increasing number of services published on the Internet, service recommendation for automatic mashup creation gains a lot of momentum. Since mashup inherently requires services with different functions, the(More)
OBJECTIVE The objectives of the study were to determine whether the cell cycle transcription factor, FoxM1, is required for glucose homeostasis and beta-cell mass expansion in maternal islets during pregnancy and whether FoxM1 is essential for placental lactogen (PL)-induced beta-cell proliferation. RESEARCH DESIGN AND METHODS beta-Cell mass, beta-cell(More)