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Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC).
TLDR
The results showed that the entrapment of 8-MOP in nanoparticulate systems could minimize the permeation differentiation between normal and hyperproliferative skin compared to the free drug in an aqueous control.
Lasers and microdermabrasion enhance and control topical delivery of vitamin C.
TLDR
The erbium:yttrium-aluminum-garnet (Er:YAG) laser showed the greatest enhancement of skin permeation of vitamin C among the modalities tested and the laser fluence and spot size were found to play important parts in controlling drug absorption.
Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage.
TLDR
Overall, results demonstrated significant benefits of chrysin on the protection of keratinocytes against UVA- and UVB-induced injuries and suggested its potential use in skin photoprotection.
Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics.
TLDR
In vitro release kinetics demonstrated that lovastatin release could be reduced by up to 60% with lipid nanoparticles containing Myverol as the lipophilic emulsifier, which showed a decreasing order of NLCs>LEs>SLNs.
Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery
TLDR
Evaluated nanostructured lipid carriers loaded with lipophilic calcipotriol and hydrophilic methotrexate suggest that NLCs may have the potential to serve as delivery carriers for antipsoriatic drugs because of enhanced drug permeation and limited skin irritation.
The effect of laser treatment on skin to enhance and control transdermal delivery of 5-fluorouracil.
TLDR
Histological changes induced by both the erbium:YAG and CO2 lasers had completely recovered within 4 days and both SC ablation and a thermal effect may contribute to the effect of the CO2 laser on skin structure.
Transdermal iontophoresis of 5-fluorouracil combined with electroporation and laser treatment.
TLDR
The laser was consistently the most potent technique to enhance 5-FU delivery among the physical enhancement methods examined in this study.
Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations.
TLDR
The experimental results suggest that SLNs may offer a promising strategy for apomorphine delivery via oral ingestion, and show 12- to 13-fold higher bioavailability than the reference solution.
Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules.
TLDR
Both in vitro and in vivo results indicated an improvement in permeant skin delivery by the laser, with the smaller molecular weight (MW) and more-hydrophilic entities showing greater enhancing effect.
Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin.
TLDR
This is the first report to establish the permeation profiles for topically applied resveratrol, and it was concluded that delivery via a skin route may be a potent way to achieve the therapeutic effects of resver atrol.
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