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Mesoporous silica MCM-41 and SBA-15 were chosen to study the adsorption and release of bulky biomolecule heparin, in order to develop new heparin controlled delivery system and expand the application of mesoporous materials in life science. To explore how the structure of support such as pore size and surface state affects the accommodation and release of(More)
A new route to modify the mesoporous silica MCM-41 with carbon, using the inherent surfactant template in the as-synthesized sample as the carbon precursor, is reported in this article. Apart from the advantage of omitting energy and time required for removal of template, the resulting silica-carbon composites exhibit a high efficiency in adsorption and(More)
A novel small-caliber vascular prosthesis prototype is proposed on the basis of a new heparin release system, that is, the controlled delivery of heparin from mesochannels. Fabrication of mesochannels on artificial biomaterials is successfully achieved through epitaxial growth of mesoporous silica nanoparticles on expanded polytetrafluoroethylene grafts,(More)
Adsorption of tobacco-specific nitrosamines (TSNA) by the functionalized MCM-48 mesoporous silica in tobacco-extract solution was studied using batch experiments, in order to explore the new strategy enhancing the efficiency of molecular sieve in the solution with complex composition. The techniques of XRD, N(2) adsorption-desorption at 77K, (29)Si MAS NMR,(More)
Novel low-cost and effective adsorbents of phenol and basic dyes were made by coating amorphous silica with hydrotalcite (HT) gel followed by soaking in alkaline solution, and the surface basic-acidic properties of resulting composites were evaluated by CO(2)-TPD, Hammett indicator method and NH(3)-TPD, respectively. Both BET surface area and microporous(More)
To enable zeolite to trap bulky environment pollutants such as tobacco specific nitrosamines (TSNAs), we tailored the porous structure of MCM-22 zeolite by desilication to obtain a sample with mesopores centered 3.5 nm, in order to promote the mass transport. The meso-MCM-22 was further functionalized with -SO(3)H group to enhance the efficiency in(More)
A novel, versatile functional mesoporous material with the structure of SBA-15 but a specific 3D net-linked morphology has been prepared by using a facile method. This material has been assessed for its ability to reduce the level of nitrosamines in tobacco smoke so that the actual effect of this material in the reduction of carcinogenic environmental(More)
Translocator Protein (18kDa, TSPO) is a mitochondrial outer membrane transmembrane protein. Its expression is elevated during inflammation and injury. However, the function of TSPO in vivo is still controversial. Here, we constructed a TSPO global knockout (KO) mouse with a Cre-LoxP system that abolished TSPO protein expression in all tissues and showed(More)
Neuronal loss caused by ischemic injury, trauma, or disease can lead to devastating consequences for the individual. With the goal of limiting neuronal loss, a number of cell death pathways have been studied, but there may be additional contributors to neuronal death that are yet unknown. To identify previously unknown cell death mediators, we performed a(More)
A new strategy, releasing nitric oxide (NO) and adsorbing nitrosamines simultaneously by zeolitic materials in the digestive system, is validated in this paper. Three types of moisture-saturated molecular sieves, HZSM-5 zeolite, mesoporous zeolite, and mesoporous silica MCM-41, are used as NO-delivery vessels in mimic gastric juice after modification of(More)