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Piwi-interacting RNAs (piRNAs) silence transposons in animal germ cells. piRNAs are thought to derive from long transcripts spanning transposon-rich genomic loci and to direct an autoamplification loop in which an antisense piRNA, bound to Aubergine or Piwi protein, triggers production of a sense piRNA bound to the PIWI protein Argonaute3 (Ago3). In turn,(More)
The effectiveness of a digital watermarking algorithm is indicated by the robustness of embedded watermarks against various attacks. Improving the robustness of a watermark so as to withstand attacks has been one of the main research objectives in digital image watermarking. The two issues of existing feature-based schemes that have to be addressed are: one(More)
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA (dsRNA) as a defense against viral infection. We identified endogenous siRNAs (endo-siRNAs), 21 nucleotides in length, that correspond to transposons and heterochromatic sequences in the somatic cells of(More)
Evaluation of automatic translation output is a difficult task. Several performance measures like Word Error Rate, Position Independent Word Error Rate and the BLEU and NIST scores are widely use and provide a useful tool for comparing different systems and to evaluate improvements within a system. However the interpretation of all of these measures is not(More)
We present an algorithm that finds an optimal schedule on a single processor for a given set of processes such that each process starts executing after its release time and completes its computation before its deadline, and a given set of precedence relations and a given set of exclusion relations defined on ordered pairs of process segments are satisfied.(More)
Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during germline development. In Drosophila, transposon-rich heterochromatic clusters encode piRNAs either on both genomic strands (dual-strand clusters) or predominantly one genomic strand (uni-strand clusters). Primary piRNAs derived from these clusters are proposed to drive a(More)
In Drosophila, microRNAs (miRNAs) typically guide Argonaute1 to repress messenger RNA (mRNA), whereas small interfering RNAs (siRNAs) guide Argonaute2 to destroy viral and transposon RNA. Unlike siRNAs, miRNAs rarely form extensive numbers of base pairs to the mRNAs they regulate. We find that extensive complementarity between a target RNA and an(More)
We study the problem of online subspace learning in the context of sequential observations involving structured perturbations. In online subspace learning, the observations are an unknown mixture of two components presented to the model sequentially - the main effect which pertains to the subspace and a residual/error term. If no additional requirement is(More)
In flies, small silencing RNAs are sorted between Argonaute1 (Ago1), the central protein component of the microRNA (miRNA) pathway, and Argonaute2 (Ago2), which mediates RNA interference. Extensive double-stranded character-as is found in small interfering RNAs (siRNAs)-directs duplexes into Ago2, whereas central mismatches, like those found in miRNA/miRNA*(More)
piRNAs guide PIWI proteins to silence transposons in animal germ cells. Reciprocal cycles of piRNA-directed RNA cleavage--catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3) in Drosophila melanogaster--expand the population of antisense piRNAs in response to transposon expression, a process called the Ping-Pong cycle. Heterotypic Ping-Pong(More)