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CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis.
In vivo and in vitro experiments indicate that CTRP5 is a novel pro-atherogenic cytokine and promotes transcytosis and oxidation of LDL in endothelial cells via up-regulation of 12/15-LOX. Expand
Increased serum TREM-1 level is associated with in-stent restenosis, and activation of TREM-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells.
Data suggest that TREM-1 is a predictive biomarker of ISR and an important mediator of cellular inflammation, migration, and proliferation in VSMCs. Expand
A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR-101b by targeting TGFβRI
- Xin Mou, Jia Wei Chen, +4 authors Yong-bin Hu
- Medicine, Chemistry
- Molecular medicine reports
- 2 September 2020
Investigating the circRNA_0000491/miR-101b/TGFβRI axis in ECM accumulation and fibrosis-associated protein expression levels of mesangial cells suggested that circRNA-0000491 may be beneficial for the development of an effective therapeutic target for DN. Expand
The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes
MHR is a convenient and effective measure in prediction of the presence and progression of subclinical carotid atherosclerosis in patients with T2DM, and Logistic regression analyses demonstrated that MHR is superior to traditional lipid parameters in association with elevated CIMT in diabetic patients. Expand
C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow.
This study suggests that CTRP1 is a mechano-sensitive proinflammatory factor that mediates disturbed flow-induced vascular barrier dysfunction and may inhibit the pathogenesis of atherosclerosis at early stage. Expand
Elevated Admission Microalbuminuria Predicts Poor Myocardial Blood Flow and 6‐Month Mortality in ST‐Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary…
The aims of this study were to evaluate the effects of admission MA on coronary blood flow and prognosis in ST‐segment elevation myocardial infarction (STEMI) patients undergoing primary PCI. Expand
Relationship of High-Density Lipoprotein-Associated Arylesterase Activity to Systolic Heart Failure in Patients with and without Type 2 Diabetes
High-density lipoprotein confers protection against cardiovascular disease partly attributable to its robust anti-oxidant activities, which is largely impaired in diabetic conditions, and impaired serum arylesterase activity in patients with HF is further reduced when comorbid with diabetes. Expand
Data on the expression and role of TREM-1 in the development of in-stent restenosis
The data presented in this article are related to the research article, which demonstrated that TREM-1 is expressed on vascular smooth cells (VSMCs) and promotes inflammation, proliferation and migration in cultured VSMCs. Expand
circRNA circ‐0001785 promotes the proliferative ability of osteosarcoma cells, acting as a ceRNA by sponging miR‐1200 to upregulate HOXB2. circ homeodomain interacting protein kinase 3 (HIPK3) is…
Circular RNAs (circRNAs) have crucial roles in various diseases; however, the mechanisms of action under‐ lying circRNAs in the occurrence and development of diabetic nephropathy (DN) remains largely… Expand
GW29-e1822 CCDC11 Promotes Cardiac Hypertrophy and Dysfunction in Response to Pressure Overload
Mutations in CCDC11, a coiled-coil domain containing protein, are associated with embryonic asymmetry including situs inversus totalis, heterotaxy syndrome, and congenital heart defects. The… Expand