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Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan
Data is reviewed on the human exposure, environmental fate, efficacy of anti-microbial activity, absorption, distribution, metabolism and elimination, endocrine disrupting effects, and toxicity of triclosan. Expand
Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
The basal gene expression profiles of 251 drug-metabolizing enzymes in untreated primary human hepatocytes from six donors, four commonly used hepatoma cell lines, and one transfected human liver epithelial cell line are characterized, providing references for researchers to choose carefully appropriate in vitro models for studies of drug metabolism and toxicity. Expand
Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.
Results suggest that several family 1 UGTs may potentially play an important role in BaP detoxification in the aerodigestive tract. Expand
Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants
Data suggest that the UGT1A4 codon 48 Leu>Val polymorphism significantly alters glucuronidation rates against TAM and its active hydroxylated metabolites, and that this polymorphism may play an important role in individual pharmacological response to TAM therapy. Expand
Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4.
The results demonstrate the importance of N-glucuronidation in the metabolism of NNAL and the role of UGT1A4 in this pathway. Expand
Correlation between UDP-Glucuronosyltransferase Genotypes and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone Glucuronidation Phenotype in Human Liver Microsomes
The data suggest that the UGT1A4 codon 24 and UGT2B7 codon 268 polymorphisms may be associated with altered rates glucuronidation and detoxification of NNAL in vivo. Expand
Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.
It is suggested that several UGTs may play an important role in the overall glucuronidation of BPD in humans, with UGT1A1, U GT1A7, UGT 1A9, U GTX1A10 and potentially UGT2B8 playing an important roles in the glucuronisation of the procarcinogenic (-)-BPD enantiomer. Expand
Review of Usnic Acid and Usnea Barbata Toxicity
  • Lei Guo, Q. Shi, +5 authors V. Frankos
  • Biology, Medicine
  • Journal of environmental science and health. Part…
  • 26 November 2008
This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action. Expand
Correlation between the UDP-Glucuronosyltransferase (UGT1A1) TATAA Box Polymorphism and Carcinogen Detoxification Phenotype
The data suggest that the UGT1A1 TATAA box polymorphism plays a role in an individual’s overall ability to detoxify benzo(a)pyrene and in cancer risk. Expand
Effect of triclosan, triclocarban, 2,2',4,4'-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis.
It is shown that triclosan, triclocarban, BDE-47, and BPA inhibited iodide uptake, but had differential effects on the expression of TH synthesis-related genes and the activity of TPO. Expand