• Publications
  • Influence
Mechanisms of drug combinations: interaction and network perspectives
Nature Reviews Drug Discovery 8, 111–128 (2009) | 10.1038/nrd2683 There are two errors in the author names: Zhiwei W. Cao should be Zhiwei Cao and Yixue X. Li should be Yixue Li.
  • 346
  • 19
Depression Detection via Harvesting Social Media: A Multimodal Dictionary Learning Solution
TLDR
We construct well-labeled depression and non-depression dataset on Twitter, and extract six depression-related feature groups covering not only the clinical depression criteria, but also online behaviors on social media. Expand
  • 57
  • 12
  • PDF
Can we understand van gogh's mood?: learning to infer affects from images in social networks
TLDR
We propose a semi-supervised framework to formulate the problem into a factor graph model for inferring authors' affects from images in social networks. Expand
  • 110
  • 11
  • PDF
Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
Contrast-enhancing magnetic resonance imaging with the liver-specific agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) has been shown to improve the detection rate ofExpand
  • 174
  • 10
  • PDF
Epoxyeicosanoid signaling in CNS function and disease.
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450 epoxygenase enzymes recognized as key players in vascular function and disease, primarily attributed to theirExpand
  • 103
  • 9
Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia.
The hypoxic environment imposes severe selective pressure on species living at high altitude. To understand the genetic bases of adaptation to high altitude in dogs, we performed whole-genomeExpand
  • 138
  • 9
Interpretable aesthetic features for affective image classification
TLDR
We propose the interpretable aesthetic features to describe images inspired by art theories, which are intuitive, discriminative and easily understandable. Expand
  • 59
  • 9
  • PDF
CaMKKβ-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation.
AIMS The manner in which hydrogen sulfide (H2S) suppresses neuroinflammation is poorly understood. We investigated whether H2S polarized microglia to an anti-inflammatory (M2) phenotype by activatingExpand
  • 70
  • 8
Hydrogen sulfide protects blood–brain barrier integrity following cerebral ischemia
By using two structurally unrelated hydrogen sulfide (H2S) donors 5‐(4‐methoxyphenyl) ‐3H‐1, 2‐dithiole‐3‐thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2S protectedExpand
  • 73
  • 8
Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting
  • F. Zhu, Chu Qin, +10 authors Y. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 18 July 2011
Many drugs are nature derived. Low drug productivity has renewed interest in natural products as drug-discovery sources. Nature-derived drugs are composed of dozens of molecular scaffolds generatedExpand
  • 157
  • 6
  • PDF