Raymond C K Chan36
Eric F C Cheung16
36Raymond C K Chan
16Eric F C Cheung
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  • Mohammad Ali Faghihi, Ming Zhang, Jia Huang, Farzaneh Modarresi, Marcel P Van der Brug, Michael A Nalls +3 others
  • 2010
BACKGROUND MicroRNAs (miRNAs) have the potential to regulate diverse sets of mRNA targets. In addition, mammalian genomes contain numerous natural antisense transcripts, most of which appear to be non-protein-coding RNAs (ncRNAs). We have recently identified and characterized a highly conserved non-coding antisense transcript for beta-secretase-1 (BACE1), a(More)
Spinal muscular atrophy (SMA), caused by the deletion of the SMN1 gene, is the leading genetic cause of infant mortality. SMN protein is present at high levels in both axons and growth cones, and loss of its function disrupts axonal extension and pathfinding. SMN is known to associate with the RNA-binding protein hnRNP-R, and together they are responsible(More)
Over the next few years, the efficient use of next-generation sequencing (NGS) in human genetics research will depend heavily upon the effective mechanisms for the selective enrichment of genomic regions of interest. Recently, comprehensive exome capture arrays have become available for targeting approximately 33 Mb or approximately 180,000 coding exons(More)
N-methyl-D-aspartate (NMDA) glutamate receptors are regulators of fast neurotransmission and synaptic plasticity in the brain. Disruption of NMDA-mediated glutamate signaling has been linked to behavioral deficits displayed in psychiatric disorders such as schizophrenia. Recently, noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical(More)
Mutations in BRCA1 and BRCA2 account for a significant proportion of hereditary breast cancers. Earlier studies have shown that inherited and sporadic tumors progress along different somatic genetic pathways and that global gene expression profiles distinguish between these groups. To determine whether genomic profiles similarly discriminate among BRCA1,(More)
Reliability is a major requirement for most safety-related systems. To meet this requirement, fault-tolerant techniques such as hardware replication and software re-execution are often utilized. In this paper, we tackle the problem of analysis and optimization of fault-tolerant task scheduling for multiprocessor embedded systems. A set of existing fault-(More)
Time-Triggered Network-on-Chip (TTNoC) is a networking concept aiming at providing both predictable and high-throughput communication for modern multiprocessor systems. The message scheduling is one of the major design challenges in TTNoC-based systems. The designers not only need to allocate time slots but also have to assign communication routes for all(More)
—Energy-efficiency is becoming one of the most critical issues in embedded system design. In Network-on-Chip (NoC) based heterogeneous Multiprocessor Systems, the energy consumption is influenced dramatically by task allocation schemes. Although various approaches are proposed to allocate tasks in an energy-efficient way, existing work does not well explore(More)
—Cache partitioning is a promising technique to reduce energy consumption of the cache subsystem for MPSoCs. Currently, most existing techniques focus primarily on static partition on core level. In this paper, we present a task-level approach and show that it outperforms core-level strategies. By taking the interference patterns of individual tasks into(More)
This study examined anticipatory and consummatory pleasure in schizophrenia patients with and without negative symptoms. Negative symptom patients experienced less anticipatory pleasure than non-negative symptom patients; only one facet of consummatory pleasure was unaffected in negative schizophrenia. Greater pleasure deficits were correlated with more(More)