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One-Class Collaborative Filtering (OCCF) is an emerging setup in collaborative filtering in which only positive examples or implicit feedback can be observed. Compared with the traditional collaborative filtering setting where the data has ratings, OCCF is more realistic in many scenarios when no ratings are available. In this paper, we propose to improve(More)
Calorie restriction (CR), the only non-genetic intervention known to slow aging and extend life span in organisms ranging from yeast to mice, has been linked to the down-regulation of Tor, Akt, and Ras signaling. In this study, we demonstrate that the serine/threonine kinase Rim15 is required for yeast chronological life span extension caused by(More)
The SIRT1 deacetylase is one of the best-studied putative mediators of some of the anti-aging effects of calorie restriction (CR), but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan than wild-type mice on an ad libitum diet. Here, we report(More)
Oncogenes contribute to tumorigenesis by promoting growth and inhibiting apoptosis. Here we examine the function of Sch9, the Saccharomyces cerevisiae homologue of the mammalian Akt and S6 kinase, in DNA damage and genomic instability during aging in nondividing cells. Attenuation of age-dependent increases in base substitutions, small DNA(More)
(WLANs). Analytical models of EDCA in the current literature have been mainly developed for the AIFS, CW, and TXOP schemes, separately. This study proposes a comprehensive analytical model to accommodate the combination of these three QoS schemes in WLANs under unsaturated traffic loads. We derive the performance metrics in terms of throughput, end-to-end(More)
A feature of the rat brain gamma-aminobutyric acid transporter GAT1, and other members of the neurotransmitter transporter family, is its regulated redistribution between intracellular locations and the plasma membrane. Recent studies have focused upon defining the signaling molecules that facilitate this redistribution. Agents that promote direct tyrosine(More)
Poly(methyl methacrylate) (PMMA) is gaining in popularity in microfluidic devices because of its low cost, excellent optical transparency, attractive mechanical/chemical properties, and simple fabrication procedures. It has been used to fabricate micromixers, PCR reactors, CE and many other microdevices. Here we present the design, fabrication,(More)
The IEEE 802.15.4 Medium Access Control (MAC) protocol is uniquely designed to meet the requirements of the low data-rate, low power-consumption applications in the Low Rate Wireless Personal Area Network (LR-WPAN). The analytical models of 802.15.4 MAC reported in the literature have been mainly developed under the assumptions of saturated traffic or(More)
In general, Web search engines perform well for users whose information needs are well-defined. When searchers can provide specific terms that adequately describe the information they are seeking, the top search results are commonly very relevant. However, when users wish to explore a topic, little assistance is provided by Web search engines to help users(More)