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Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.
TLDR
Tregs are associated with HCC invasiveness, and intratumoral balance of regulatory and cytotoxic T cells is a promising independent predictor for recurrence and survival in HCC.
Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma.
  • Jian Zhou, Lei Yu, Jia Fan
  • Medicine, Biology
    Journal of clinical oncology : official journal…
  • 20 December 2011
TLDR
A plasma microRNA panel that has considerable clinical value in diagnosing early-stage HCC is identified and patients who would have otherwise missed the curative treatment window can benefit from optimal therapy.
Systemic Immune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular Carcinoma
TLDR
The novel systemic immune-inflammation index (SII) based on lymphocyte, neutrophil, and platelet counts was a powerful prognostic indicator of poor outcome in patients with HCC and is a promising tool for HCC treatment strategy decisions.
A decade’s studies on metastasis of hepatocellular carcinoma
TLDR
A molecular signature that can classify metastatic HCC patients is generated, osteopontin is identified as a lead gene in the signature, and it is found that genes favoring metastasis progression were initiated in the primary tumors.
STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4
TLDR
HXD-AS1 is a prognostic marker for HCC patients and it may play a pro-metastatic role in hepatocarcinogenesis, and the results revealed that STAT3 could specifically interact with the promoter of HOXD -AS1 and activate HOXd-as1 transcription.
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling.
TLDR
Results showed how FAP-STAT3-CCL2 signaling in CAFs was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.
Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma
TLDR
The data suggest for the first time that PD-L1 status may be a new predictor of recurrence for HCC patients and provide the rationale for developing a novel therapy of targeting the PD- L1/PD-1 pathway against this fatal malignancy.
Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma.
TLDR
Findings indicate hsa_circ_0001649 might serve as a novel potential biomarker for HCC and may function in tumorigenesis and metastasis of HCC.
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