Jia-Chang Chen

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In this study, the motor deficit, cognition impairment and the vulnerability of different striatal interneurons to the 6-hydroxydopamine (6-OHDA)-induced excitotoxicity in unilateral medial forebrain bundle (MFB) lesion rats were analyzed by employing behavioral test, immunohistochemistry and Western blot methods. The apomorphine-induced rotation after MFB(More)
Erythropoietin (EPO) may become a potential therapeutic candidate for the treatment of the neurodegenerative disorder — Parkinson’s disease (PD), since EPO has been found to prevent neuron apoptosis through the activation of cell survival signalling. However, the underlying mechanisms of how EPO exerts its neuroprotective effect are not fully elucidated.(More)
Attention-Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood. Genetic associations have been reported between ADHD and polymorphic variants within or near dopamine pathway genes. Synaptosomal-associated protein, 25 kDa (SNAP-25), a presynaptic plasma membrane protein with an integral role in synaptic transmission, has(More)
Our previous studies had confirmed that both 3-NP and MCAO induced the behavioral defect as well as striatal neuronal injury and loss in experimental rats. This study aimed to examine different response forms of striatal astrocyte and microglia in 3-NP and MCAO rat models. The present results showed that the immunoreaction for GFAP was extremely weak in the(More)
Mars500 study was a psychological and physiological isolation experiment conducted by Russia, the European Space Agency, and China, in preparation for an unspecified future manned spaceflight to the planet Mars. Its intention was to yield valuable psychological and medical data on the effects of the planned long-term deep space mission. In this paper, we(More)
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