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Neuronal autophagy and neurodegenerative diseases
Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. The integrity of postmitotic neurons is heavilyExpand
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A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
Our previous microarray analysis identified a neuroprotective protein Oxi‐α, that was down‐regulated during oxidative stress (OS)‐induced cell death in dopamine neurons [Neurochem. Res. (2004) vol.Expand
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Tnfaip8 l1/Oxi‐β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model
Abnormal autophagy may contribute to neurodegeneration in Parkinson's disease (PD). However, it is largely unknown how autophagy is dysregulated by oxidative stress (OS), one of major pathogenicExpand
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Hypolipidemic effect of an exo-biopolymer produced from submerged mycelial culture of Auricularia polytricha in rats
The hypolipidemic effect of an exo-biopolymer (EBP) produced from a submerged mycelial culture of the mushroom fungus, Auricularia polytricha, was investigated in the dietary-induced hyperlipidemicExpand
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Simultaneous activation of mitophagy and autophagy by staurosporine protects against dopaminergic neuronal cell death
Abnormal autophagy is frequently observed during dopaminergic neurodegeneration in Parkinson's disease (PD). However, it is not yet firmly established whether active autophagy is beneficial orExpand
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Nitric Oxide Induction of Parkin Translocation in PTEN-induced Putative Kinase 1 (PINK1) Deficiency
Background: A novel mechanism underlying mitochondrial translocation of Parkin during mitophagy is uncovered. Results: nNOS plays a significant role in Parkin translocation via interaction withExpand
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The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells.
The nature of mitochondrial dysfunction in dopaminergic neurons in familial Parkinson's disease (PD) is unknown. We characterized the pathophenotypes of dopaminergic neuronal cells that wereExpand
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Production of Exo-Polymers by Submerged Mycelial Culture of Cordyceps militaris and Its Hypolipidemic Effect
Hypolipidemic effect of exo-polymers(EPs) form submerged mycelial culture of Cordyceps militaris was investigated in male Sprague-Dawley rats. For a dose-dependent study, EPs were administered at theExpand
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The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
Defective hepatic autophagy is observed in obesity and diabetes, whereas autophagy is inhibited by insulin in hepatocytes. Insulin-induced anti-autophagy is mediated by non-canonical Gαi3 signalingExpand
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A Novel Non‐Apoptotic Role of Procaspase‐3 in the Regulation of Mitochondrial Biogenesis Activators
The executioner caspase‐3 has been proposed as a pharmacological intervention target to preserve degenerating dopaminergic (DA) neurons because apoptotic mechanisms involving caspase‐3 contribute, atExpand
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