Ji-feng Xiang

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AMFR, autocrine motility factor receptor, also called gp78, is a cell surface cytokine receptor which has a dual role as an E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. AMFR expression is associated with tumor malignancy. We here investigated the clinical significance of AMFR and its role in metastasis and prognosis in gastric(More)
Cellular response to DNA double-strand breaks (DSBs), the most deleterious type of DNA damage, is highly influenced by higher-order chromatin structure in eukaryotic cells. Compared with euchromatin, the compacted structure of heterochromatin not only protects heterochromatic DNA from damage, but also adds an extra layer of control over the response to DSBs(More)
Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries (WHO, 2008), one in four deaths is due to cancer in American each year (Siegel et al., 2013). Although the incidence and mortality of gastric cancer (GC) is declining, it remains the fourth most common epithelial malignancy(More)
OBJECTIVE To investigate the potential effects on cognitive function, prognosis, and neuropeptide levels of patients in response to combination therapy with ornithine aspartate plus naloxone for hepatic encephalopathy. METHODS Eighty-four consecutive patients diagnosed with hepatic encephalopathy were randomly divided into two equal groups. The control(More)
Phosphorylated histone H2AX, termed 'γH2AX', mediates the chromatin response to DNA double strand breaks (DSBs) in mammalian cells. H2AX deficiency increases the numbers of unrepaired DSBs and translocations, which are partly associated with defects in non-homologous end joining (NHEJ) and contributing to genomic instability in cancer. However, the role of(More)
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