Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
This study suggests that downregulation of GPX4 during MI contributes to ferroptotic cell death in cardiomyocytes upon metabolic stress such as cysteine deprivation.
HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics
HepG2 cells are suggested as a cell-based model in screening for CYP inducers in drug discovery because of more similarity to human liver than the other cell lines in comparisons of the expression of cellular proteins.
Inhibition of cytochrome P450 by ethambutol in human liver microsomes.
Assessment of drug-drug interactions caused by metabolism-dependent cytochrome P450 inhibition.
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice
Zerumbone is a promising agent for the prevention of both tumor initiating and promoting processes, through induction of anti‐oxidative and phase II drug metabolizing enzymes as well as attenuation of proinflammatory signaling pathways.
Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer.
- Ji-Yoon Lee, M. Nam, Sang Chul Lee
- BiologyProceedings of the National Academy of Sciences…
- 7 December 2020
The expression of elongation of very long-chain fatty acid protein 5 (ELOVL5) and fatty acid desaturase 1 (FADS1) is up-regulated in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization, and the polyunsaturated fatty acid (PUFA) biosynthesis pathway plays an essential role in ferroPTosis.
Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin.
Findings suggest that IH-901 exerts anti-inflammatory effects by inhibiting TPA-induced COX-2 expression, which may contribute to its antitumor-promoting effects on mouse skin carcinogenesis.
Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism.
Inhibition of phorbol ester‐induced COX‐2 expression by some edible African plants
It is found that methanol extracts of CB, DEV, RT, and BB inhibited, to a different extent, 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced COX‐2 expression in human breast epithelial cells and in mouse skin in vivo.
Lipid Metabolism and Ferroptosis
Current knowledge of how various lipid metabolic pathways are associated with lipid peroxidation and ferroptosis is summarized to provide insight into treatment strategies for ferroPTosis-related diseases.