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In situ Detection of a Single Bacterium in Complex Environment by Hyperspectral CARS Imaging
Detection of bacteria is essential for clinical diagnosis of infectious disease and food safety purposes. However, it is still a challenging task to rapidly detect bacteria, especially in their… Expand
Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium
Abstract Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with appropriate antibiotics and slowing down the emergence of antibiotic‐resistant bacteria.… Expand
Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography.
- Brittani Bungart, Ying-Chun Cao, +7 authors Ji-Xin Cheng
- Materials Science, Medicine
- Biomedical optics express
- 1 March 2019
We develop a urethral device with cylindrical illumination for whole-prostate imaging, and its performance as a function of angular light coupling is evaluated with a prostatic phantom. Expand
Label-free quantitation of glycated hemoglobin in single red blood cells by transient absorption microscopy and phasor analysis
Transient absorption microscopy could detect HbA1c, which is a stable biomarker for diabetes, at single–red blood cell level. As a stable and accurate biomarker, glycated hemoglobin (HbA1c) is… Expand
Transient absorption microscopy: Technological innovations and applications in materials science and life science.
Transient absorption (TA) spectroscopy has been extensively used in the study of excited state dynamics of various materials and molecules. The transition from TA spectroscopy to TA microscopy, which… Expand
Multiplex Stimulated Raman Scattering Imaging Cytometry Reveals Lipid-Rich Protrusions in Cancer Cells under Stress Condition
Summary In situ measurement of cellular metabolites is still a challenge in biology. Conventional methods, such as mass spectrometry or fluorescence microscopy, would either destroy the sample or… Expand
Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA
Abstract Confronted with the rapid evolution and dissemination of antibiotic resistance, there is an urgent need to develop alternative treatment strategies for drug‐resistant pathogens. Here, an… Expand
A Thermodynamic Interpretation of the Stimulated Raman Spectroscopic Signature of an Action Potential in a Single Neuron
It has previously been suggested that the plasma membrane condenses and melts reversibly during an action potential in a neuron, analogous to an acoustic wave travelling in the compressive membrane… Expand
Functionalized NIR-II Semiconducting Polymer Nanoparticles for Single-cell to Whole-Organ Imaging of PSMA-Positive Prostate Cancer.
Development of molecular probes holds great promise for early diagnosis of aggressive prostate cancer. Here, 2-[3-(1,3-dicarboxypropyl) ureido] pentanedioic acid (DUPA)-conjugated ligand and… Expand
Dual-wavelength photo-killing of methicillin-resistant Staphylococcus aureus.
With the effectiveness of antimicrobials declining as antimicrobial resistance continues to threaten public health, we must look to alternative strategies for the treatment of infections. In this… Expand