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Clinical studies have shown that the tyrosine kinase inhibitor STI571 effectively controls BCR-ABL-positive chronic myelogenous leukemia (CML). However, disease progression while on STI571 therapy has been reported, suggesting de novo or intrinsic resistance to BCR-ABL-targeted therapy. To investigate possible mediators of acquired STI571 resistance, K562(More)
In a distributed processing environment, the static placement of query operators may result in unsatisfactory system performance due to unpredictable factors such as changes of servers' load, data arrival rates, etc. The problem is exacerbated for continuous (and long running) monitoring queries over data streams as any suboptimal placement will affect the(More)
Recently, a new clustering method called maximum margin clustering (MMC) was proposed and has shown promising performances. It was originally formulated as a difficult nonconvex integer problem. To make the MMC problem practical, the researchers either relaxed the original MMC problem to inefficient convex optimization problems or reformulated it to(More)
Web applications have become complex and crucial in many fields. In order to assure their quality, a high demand for systematic methodologies of Web application testing is emerging. In this paper, a methodology of Model-Driven Testing (MDT) for Web application is presented. Model is the core of this method. Web application model is built to describe the(More)