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LPA receptors: subtypes and biological actions.
TLDR
This work has provided valuable proof-of-concept data to support LPA receptors and LPA metabolic enzymes as targets for the treatment of medically important diseases that include neuropsychiatric disorders, neuropathic pain, infertility, cardiovascular disease, inflammation, fibrosis, and cancer. Expand
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
TLDR
Receptor rescue and pharmacological experiments supported the loss of S1P1 on astrocytes through functional antagonism by FTY720-P as a primary FTY 720 mechanism and implicate S1p signaling pathways within the CNS as targets for multiple sclerosis therapies. Expand
Lysophospholipids and their receptors in the central nervous system.
TLDR
This review will provide an overview and update on the biological functions of LPA and S1P signaling in the central nervous system, with a focus on results from studies using genetic null mutants for LPA-S1P receptors. Expand
Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization
TLDR
This study identified S1P3 as a pathogenic mediator in an ischemic brain along with underlying mechanisms, involving its modulation of microglial activation and M1 polarization, further suggesting that S 1P3 can be a therapeutic target for cerebral ischemia. Expand
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes
TLDR
The results suggest that the activation of PAR1 mediates thrombin-induced MMP-9 expression through the regulation of Erk1/2. Expand
Biological roles of lysophospholipid receptors revealed by genetic null mice: an update.
TLDR
This review will focus on findings from in vivo as well as in vitro studies using genetic null mice for the LP receptors, LPA1,2,3 and S1P1, 2,3,5, and for theLP producing enzymes, autotaxin and sphingosine kinase 1/2. Expand
Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus
TLDR
It is reported that lysophosphatidic acid (LPA), a blood-borne lipid that activates signaling through heterotrimeric guanosine 5′-triphosphate–binding protein (G protein)–coupled receptors, provides a molecular explanation for FH associated with hemorrhage. Expand
Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis
TLDR
Observations that support an emerging neurological MOA for FTY720 in MS may also involve a direct, neurological action within the central nervous system in view of documented S1P receptor-mediated signaling influences in the brain. Expand
Predictive Factors of the Outcome of Extracorporeal Shockwave Lithotripsy for Ureteral Stones
TLDR
Stone size is an independent predictive factor influencing failure of ESWL for treating ureteral stones, and in larger ureters, the presence of perinephric fat stranding is also anindependent predictive factor. Expand
The complex morphology of reactive astrocytes controlled by fibroblast growth factor signaling
TLDR
Results indicate that FGF8–FGFR3 signaling controls structural changes in astrocytes during reactive gliosis, under pathogenic conditions. Expand
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