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The method of intracerebroventricular (i.c.v.) injection of drugs to conscious mice is a simple and useful technique for studying the central actions of drugs in mice. However, the use of this technique to dissect the central regulatory mechanisms of stress-activated hypothalamo-pituitary-adrenocortical (HPA) axis may produce confusing results difficult to(More)
Expression of the carboxyl-terminal fragment (CT) of the beta-amyloid precursor protein (APP) in transgenic animals has been linked with neurotoxicity. However, it remains to be clarified whether the neurotoxicity is caused by beta-amyloid proteins (A betas) derived from CT or by CT itself. To study the in vivo neurotoxicity of CT, mice were given a single(More)
To investigate the modulatory roles of central gamma-aminobutyric acid (GABA)A and GABAB receptors in the regulation of basal and stress-induced plasma interleukin-6 (IL-6) levels, we examined the effects of i.c.v. injection of GABA receptor agonists and antagonists on basal and restraint stress-induced plasma IL-6 levels in mice. Muscimol (20-200 ng), a(More)
BACKGROUND The underlying mechanisms involved in the activation of hypoxia-inducible factor-1 (HIF-1) in gastric cancer remain unclear. As nuclear factor-κB (NF-κB) as well as HIF-1 have been implicated in angiogenesis of various cancers, we investigated their relationship in gastric cancer. METHODS Nuclear expressions of HIF-1α and NF-κB/RelA were(More)
We studied the effects of p-synephrine on the immobility behaviors and on the spontaneous motor activity in mice. p-Synephrine at oral doses from 1 to 10 mg/kg significantly decreased the duration of immobility in the tail suspension test and the forced swimming test in mice. At 30 mg/kg, the duration of immobility was returned to control values in both(More)
MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclopepten-5,10-imine maleate), a non-competitive NMDA receptor antagonist (0.01-1 micrograms), injected intracerebroventricularly (i.c.v.) dose dependently increased the baseline levels of plasma interleukin-6 in mice. In the 1-h immobilization-stressed animals, MK-801 (1 micrograms) administered i.c.v.(More)
OBJECTIVE To investigate the prognostic factors predicting the recovery of pre-fracture functional mobility, we evaluated this by the use of ambulatory assistive devices in short-term follow-up. METHODS Five hundred and fifty-three elderly patients who had undergone hip fracture operations from January 2006 to June 2013 were enrolled in this retrospective(More)
OBJECTIVE To evaluate the overall profile of children with feeding disorders and their relationships to medical conditions in an outpatient feeding clinic of a tertiary hospital. METHODS The medical records of 143 children who had visited the feeding clinic between January 2010 and June 2014 were reviewed retrospectively. The presence of a feeding(More)
OBJECTIVE To predict ambulatory capacity, 1 month after physical therapy following hip fracture surgery. METHODS A retrospective chart review was carried out. Patients more than 60 years old, who underwent hip fracture surgery and received physical therapies, were selected (n=548). Age, gender, presence of cognitive dysfunction, combined medical diseases,(More)
Using a wireless sensor network, variety applications are being developed. In this paper, considering the field of military surveillance and reconnaissance sensors in the network for network configuration in the clustering method to elect a cluster head is about technology. Clustering of a sensor nodes elect to cluster head from among the sensor nodes and(More)