Ji Ryang Chung

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Connectomics is the study of the full connection matrix of the brain. Recent advances in high-throughput, high-resolution 3D microscopy methods have enabled the imaging of whole small animal brains at a sub-micrometer resolution, potentially opening the road to full-blown connectomics research. One of the first such instruments to achieve whole-brain-scale(More)
In this paper, we will review a novel microscopy modality called Knife-Edge Scanning Microscopy (KESM) that we have developed over the past twelve years (since 1999) and discuss its relevance to connectomics and neural networks research. The operational principle of KESM is to simultaneously section and image small animal brains embedded in hard polymer(More)
A large number of neural network models are based on a feedforward topology (perceptrons, backpropagation networks, radial basis functions, support vector machines, etc.), thus lacking dynamics. In such networks, the order of input presentation is meaningless (i.e., it does not affect the behavior) since the behavior is largely reactive. That is, such(More)
Major advances in high-throughput, high-resolution, 3D microscopy techniques have enabled the acquisition of large volumes of neuroanatomical data at submicrometer resolution. One of the first such instruments producing whole-brain-scale data is the Knife-Edge Scanning Microscope (KESM), developed and hosted in the authors' lab. KESM has been used to(More)
Early primitive animals with simple feed-forward neuronal circuits were limited to reactive behavior. Through evolution, they were gradually equipped with memory and became able to utilize information from the past. Such memory is usually implemented with recurrent connections and certain behavioral changes are thought to precede the reconstitution of the(More)
What is time? Since the function of the brain is closely tied in with that of time, investigating the origin of time in the brain can help shed light on this question. In this paper, we propose to use simulated evolution of artificial neural networks to investigate the relationship between time and brain function, and the evolution of time in the brain. A(More)
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