• Publications
  • Influence
A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.
A new triterpenoid named alisol O was isolated from the rhizomes of Alisma orientalis, together with six known compounds, which exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.
A new Pinoresinol-type lignan from Ligularia Kanaitizensis
A new pinoresinol-type Lignan was isolated from the roots and rhizomes of Ligularia kanaitizensis (Franch.) Hand.-Mazz and showed that 1 was inhibitory to HIV-1 RT.
Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis.
These compounds might contribute to anti-HIV-1 activities extracts of the medicinal plant Rhus chinensis and might target late-steps of HIV-1 life cycle.
Iridoid glycosides from Harpagophytum procumbens D.C. (devil's claw).
Compound 10 showed marginal inhibition activity against macrophages respiratory burst in Harpagophytum prucumbens D.C.
Anti-HBV active constituents from Piper longum.
In the screening search for Hepatitis B virus inhibitory agents from medicinal plants, the ethanol extract of Piper longum Linn was found to possess superior anti-HBV activity in vitro, and the compound piperine possessed remarkable inhibitory HBV activity.
Two new compounds and anti-HIV active constituents from Illicium verum.
Two new compounds named illiverin A (1) and tashironin A (8) were isolated from the roots of Illicium verum, together with seven known compounds:
The anti-HIV-1 effect of scutellarin.
Scutellarin was found to inhibit several strains of HIV-1 replication with different potencies, and appeared to inhibit HIV- 1 RT activity, HIV-2 particle attachment and cell fusion, which are essential activities for viral transmission and replication.
Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
Interestingly, compound 4e could inhibit not only HBsAg and HBeAg secretions but also HBV DNA replication with SI values of 20.3, 125.0 and 104.9.
UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis.
The results of this investigation support the ethnopharmacological use of Artemisia capillaris as anti-HBV agents and show that carboxyl group is closely associated to the anti- HBV activity.
Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.
Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known