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OBJECTIVE Aberrant thalamocortical network has been hypothesized to play a crucial role in the fundamental pathogenesis underlying idiopathic generalized epilepsy (IGE). We aimed to investigate alterations of thalamocortical functional network in patients with IGE using thalamic seed-based functional connectivity (FC) analysis, and their relationships with(More)
PURPOSE Previous neuroimaging studies provide growing evidence that patients with juvenile myoclonic epilepsy (JME) have both structural and functional abnormalities of the thalamus and frontal lobe gray matter. However, limited data are available regarding the issue of white matter (WM) involvement, making the microstructural WM changes in JME largely(More)
BACKGROUND AND OBJECTIVES Free fatty acids (FFAs), an important energy substrate, have an association with cardiovascular diseases, such as atherosclerosis, myocardial dysfunction and abnormal cardiac rhythm. However, limited reports are available on the association between FFAs and ischemic stroke. We hypothesized that plasma FFA concentration could be(More)
BACKGROUND Although long-term predictors of mortality and vascular events after ischemic stroke are well defined, the age-dependent differences in predicting outcomes are unknown, particularly for lipid parameters. METHODS We assessed recurrent stroke and other vascular events in patients with first-ever ischemic strokes who were registered in a(More)
Visual assessment of structural MRI is, by definition, normal in patients with juvenile myoclonic epilepsy (JME), a major subsyndrome of idiopathic generalized epilepsy (IGE). However, recent quantitative MRI studies have shown structural abnormalities in cortical and thalamic grey matter (GM) in JME. Voxel-based morphometry (VBM) is a fully automated,(More)
Previous studies using voxel-based morphometry (VBM) provided emerging evidence of structural changes of the thalamus in idiopathic generalized epilepsy (IGE). However, the location of atrophy within the thalamus in IGE has been somewhat inconsistent across the studies. We, therefore, examined the location of thalamic atrophy and its relationship with(More)
PURPOSE To assess the relationship between visual function and macular ganglion cell complex (GCC) thickness measured by Fourier-domain optical coherence tomography (OCT) and to evaluate the diagnostic value of GCC thickness for detecting early, moderate, and severe glaucoma. METHODS Participants underwent reliable standard automated perimetry testing and(More)
The aim of present study was to identify the common propagation pattern of ictal discharges in mesial temporal lobe epilepsy (TLE). Pre-surgical ictal scalp EEG recordings were collected from patients with TLE associated with hippocampal sclerosis. Two types of ictal onset patterns were identified based on spatial and spectral characteristics of initial(More)