Ji Hye Yoon

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Neurodegenerative disorders are strongly associated with oxidative stress, which is induced by reactive oxygen species including hydrogen peroxide (H₂O₂). Epidemiological studies have suggested that coffee may be neuroprotective, but the molecular mechanisms underlying this effect have not been clarified. In this study, we investigated the protective(More)
AIM A pen and paper Token Test utilizing binary scoring of accuracy-inaccuracy in responses evaluates linguistic functions including verbal comprehension. However, the test might not be sensitive enough to detect the aging effect on performance in normal older adults unless the test utilizes a multidimensional scoring system. We hypothesized that the(More)
BACKGROUND Agraphia in Korean patients may be different from agraphia in other patients who use alphabetical writing systems due to the "visuoconstructional script" characteristics of the Korean writing system, Hangul. Patients with early onset Alzheimer's disease (EOAD) have a severe degree of hypometabolism in the parietal area, which is known to be(More)
OBJECTIVES We investigated how changes in the writing of 14 Korean stroke patients reflect the unique features of the Korean writing system. BACKGROUND The Korean writing system, Han-geul, has both linguistic and visuospatial/constructive characteristics. In the visuospatial construction of a syllable, the component consonant(s) and vowel(s) must be(More)
BACKGROUND In writing, linguistic (i.e., spelling) and nonlinguistic (i.e., arranging strokes or letters) functions are processed by the left and right hemispheres, respectively. The configuration of Korean alphabet, 'Hangul' invokes nonlinguistic, visuospatial functions that other writing systems use less extensively. Patients with Alzheimer's disease (AD)(More)
Alzheimer’s disease (AD) is becoming a growing global problem, and there is an urgent need to identify reliable blood biomarkers of the risk and progression of this condition. A potential candidate is the brain-derived neurotrophic factor (BDNF), which modulates major trophic effects in the brain. However, findings are apparently inconsistent regarding(More)
AIM The purpose of the present study was to investigate if performance in a 30-s verbal semantic fluency task (i.e. animal naming) across five elderly aged groups (60-64; 65-69; 70-74; 75-79; 80-84 years) would be reflective of aging effect. METHODS We analyzed differences in performance across 5-s phases and the moment of first word production in these(More)
AIM First, we objectively quantified the handwriting size of Parkinson's disease (PD) patients. Second, we investigated the efficacy of the external visual cueing on Korean handwriting in PD. METHODS We recruited 57 patients diagnosed with PD and 37 community-dwelling normal older adults. All participants were asked to write a target word on a blank sheet(More)
AIM The aim of the present study was to delineate how age-related deterioration affects the handwriting of healthy elderly (HE) subjects. METHODS A total of 235 HE (54 males, 181 females) aged 57-91 years participated as subjects in the study. In order to compare the area of handwriting, we divided the participants into two groups: (i) aged 57-74 years;(More)