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Differential evolution (DE) is a novel evolutionary approach capable of handling non-differentiable, nonlinear and multi-modal objective functions. Previous studies have shown that DE is an efficient, effective and robust evolutionary algorithm, but usually it takes large computational time for optimizing the computationally expensive objective function,(More)
OBJECTIVE Glucocorticoid receptor alpha (GRalpha) is crucial for glucocorticoids (GC) to carry out their physiological and pharmacological roles. Studies have shown the disorder of GR-GC systems in autoimmune diseases. Our study was performed to test the relationship between GRalpha expression and disease activity of systemic lupus erythematosus (SLE). (More)
AIM To study the NKT cell subsets and their differentiation. METHODS Splenic lymphocytes from C57BL/J mice that had received SEB treatment were collected as effector cells on the 10(th) day. The cells were cultured in medium containing ConA, LPS and IL-2 for 3 days and measured their response to mitogens and cytokine. The inhibitory action of the effector(More)
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