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Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
TLDR
The results suggest that crosstalk between oxygen- and redox-responsive signal transducers occurs through the SIRT1-HIF-1alpha interaction. Expand
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
TLDR
It is reported that the oncogenic melanocyte lineage-specification transcription factor MITF drives PGC1α (PPARGC1A) overexpression in a subset of human melanomas and derived cell lines. Expand
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
TLDR
A cAMP-induced phosphorylation of a highly conserved serine (S434) located in the SIRT1 catalytic domain that rapidly enhanced intrinsic deacetylase activity independently of changes in NAD(+) levels is identified. Expand
Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell proliferation.
TLDR
It is suggested that hARD1 participates in proliferation of lung cancer cells via the activation of beta-catenin through the inhibition of hard1-silencing RNA and the down-regulated promoter activity of cyclin D1. Expand
Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy
TLDR
This review describes the morphological and molecular aspects of various IR-induced types of cell death and proposes radiation-sensitization strategies that can counteract the resistance of tumors to IR. Expand
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis
TLDR
Findings reveal that PGC1α maintains mitochondrial energetic metabolism and suppresses metastasis through direct regulation of parallel acting transcriptional programs, defining new therapeutic opportunities that may help to curb melanoma metastasis. Expand
Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex*
TLDR
Oleic acid stimulates the cAMP/protein kinase A pathway and activates the SIRT1-PGC1α transcriptional complex to modulate rates of fatty acid oxidation to illustrate how a single long chain fatty acid specifically controls lipid oxidation through a signaling/transcriptional pathway. Expand
Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin.
TLDR
HIF-1alpha was found to inactivate the Wnt signaling by binding to hARD1 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells. Expand
Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1α
TLDR
Bafilomycin A1 and its analog, concanamycin A, were found to up-regulate HIF-1α in eight human cancer cell-lines, and this effect is attributed to inhibited degradation of Hif-1 α protein. Expand
Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression
TLDR
This work reports that in mice insulin activates cyclin D1–cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression, and identifies a Cdk4 inhibitor that potently decreases PGC-1α acetylation. Expand
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