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Carbohydrate recognition plays an important role in the development of normal projections of sensory afferent neurons in the leech CNS. Four different carbohydrate epitopes are expressed by sensory afferents on their 130 kDa surface proteins: all sensory afferents share a common carbohydrate epitope (CE0) that helps them to enter and project diffusely(More)
We studied carbohydrate interactions that mediate the targeting of sensory afferents in the synaptic neuropil of segmental central nervous system (CNS) ganglia in the embryonic leech. First, we determined the rate of sensory afferent development in vivo, and then we devised a culture system that permits the normal patterning of their projections in the CNS(More)
Introduction: Mesenchymal stem cells (MSCs) are the best candidates for tissue engineering and cell-based therapeutic strategies, such as the treatment of mesenchymal tissue injuries (1). In recent years, investigators have evaluated novel sources of allogeneic MSCs, including bone marrow, umbilical cord blood (UCB) and possible tissues such as synovium,(More)
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